{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:48:38Z","timestamp":1777891718093,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n The significance of changes in P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n during long-term noninvasive ventilation (NIV) on prognosis remains unclear. We aimed to clarify whether stabilizing P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n during NIV had a favorable prognostic effect.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n Data from 190 subjects with restrictive thoracic disease and who received long-term NIV were studied retrospectively. The annual change in P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n during NIV was determined using a simple linear regression method for each subject who had at least 4 6-month intervals of P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n data. Annual changes in P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n during long-term NIV and possible confounders were analyzed with discontinuation of long-term NIV as the main outcome.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n One hundred and twenty-five subjects who had > 4 6-month intervals of P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n data were included in the study. P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n during long-term NIV decreased in 41 subjects (group 1; < 0 mm Hg\/y), increased slightly in 42 subjects (group 2; between 0 and 1.85 mm Hg\/y), and increased significantly in 42 subjects (group 3; > 1.85 mm Hg\/y). Smaller annual changes in P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n (\n P<\/jats:italic>\n < .001) and a control ventilator mode (\n P<\/jats:italic>\n = .008) were associated with a significantly higher probability of continuing NIV, compared with decreased P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n 3\u20136 months after the start of long-term NIV (\n P<\/jats:italic>\n = .11). The 10-y probability of continuing NIV was 69% in group 1, 39% in group 2, and 12% in group 3.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n A decrease in the annual change of P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n during long-term NIV was shown to be a significantly prognostically favorable factor. Efforts to reduce P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n should be made if P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n increases at a greater rate during long-term NIV.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.02829","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T04:26:11Z","timestamp":1405484771000},"page":"1671-1678","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The Importance of Controlling P\n \n aCO\n 2<\/sub>\n <\/sub>\n Throughout Long-Term Noninvasive Ventilation"],"prefix":"10.1177","volume":"59","author":[{"given":"Tomomasa","family":"Tsuboi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Minami-Kyoto Hospital, Kyoto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Oga","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Sumi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Minami-Kyoto Hospital, Kyoto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Machida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Tokyo Hospital, Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoharu","family":"Ohi","sequence":"additional","affiliation":[{"name":"Sleep Medical Centre, Osaka Kaisei Hospital, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.66.2.112"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.494"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.04091044"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0921"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.039388"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1326"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.657"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.10.012"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00404302"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.100"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.6.604"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.04.015"},{"issue":"2","key":"e_1_3_2_14_2","first-page":"99","article-title":"Long-term follow-up of ventilated patients with thoracic restrictive or neuromuscular disease","volume":"9","author":"Brooks D","year":"2002","unstructured":"Brooks D, , De Rosie J, , Mousseau M, , Avenda\u00f1o M, , Goldstein RS. Long-term follow-up of ventilated patients with thoracic restrictive or neuromuscular disease. Can Respir J, 2002; 9(2):99\u2013106.","journal-title":"Can Respir J"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.6.1828"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1522"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.07.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633704"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4310"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088712"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.04.027"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.13115299"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.08.013"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.124263"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.08.014"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0253"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.02829","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.02829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.02829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:09:36Z","timestamp":1777615776000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.02829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,15]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.4187\/respcare.02829"],"URL":"https:\/\/doi.org\/10.4187\/respcare.02829","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,15]]}}}