{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:31:31Z","timestamp":1782833491199,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2015,3]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Several new generation neonatal ventilators that incorporate conventional as well as high frequency ventilation (HFOV) have appeared on the market. Most of them offer the possibility to use HFOV in a volume-targeted mode, despite absence of any preclinical data. With a bench test, we evaluated the performances of 4 new neonatal HFOV devices and compared them to the SensorMedics HFOV device.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n Expiratory tidal volumes (V\n T<\/jats:sub>\n ) were measured for various ventilator settings and lung characteristics (ie, modifications of compliance and resistance of the system), to mimic several clinical conditions of pre-term and term infants.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Increasing the frequency proportionally decreased the V\n T<\/jats:sub>\n for all the ventilators, although the magnitude of the decrease was highly variable between ventilators. At 15 Hz and a pressure amplitude of 60 cm H\n 2<\/jats:sub>\n O, the delivered V\n T<\/jats:sub>\n ranged from 3.5 to 5.9 mL between devices while simulating pre-term infant conditions and from 2.6 to 6.3 mL while simulating term infant conditions. Activating the volume-targeted mode in the 3 machines that offer this mode allowed the V\n T<\/jats:sub>\n to remain constant over the range of frequencies and with changes of lung mechanical properties, for pre-term infant settings only while targeting a V\n T<\/jats:sub>\n of 1 mL.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n These new generation neonatal ventilators were able to deliver adequate V\n T<\/jats:sub>\n under pre-term infant, but not term infant respiratory system conditions. The clinical relevance of these findings will need to be determined by further studies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.03048","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:34:19Z","timestamp":1416357259000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance"],"prefix":"10.1177","volume":"60","author":[{"given":"Serge","family":"Grazioli","sequence":"first","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, University Hospital of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Karam","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, University Hospital of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C","family":"Rimensberger","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, University Hospital of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"issue":"3","key":"e_1_3_3_2_2","first-page":"CD000104","article-title":"Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants","author":"Cools F","year":"2009","unstructured":"Cools F, , Henderson-Smart DJ, , Offringa M, , Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev, 2009;(3):CD000104.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60278-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012750"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318219673e"},{"key":"e_1_3_3_6_2","first-page":"593915","article-title":"High-frequency oscillatory ventilation combined with volume guarantee in a neonatal animal model of respiratory distress syndrome","author":"Sanchez Luna M","year":"2013","unstructured":"Sanchez Luna M, , Santos Gonzalez M, , Tendillo Cortijo F. High-frequency oscillatory ventilation combined with volume guarantee in a neonatal animal model of respiratory distress syndrome. 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