{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:49:10Z","timestamp":1777891750897,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The 2009 pandemic influenza A (H1N1) virus was accompanied by high morbidity and mortality. The aim of this study was to describe the clinical characteristics of patients with documented 2009 influenza A (H1N1) virus admitted to a reference chest hospital, the disease outcome, and risk factors associated with ICU admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We assessed 109 subjects admitted to the respiratory infection unit of a hospital for chest disease with signs and symptoms of the 2009 influenza A (H1N1) virus between April 2009 and December 2010. Demographic data, comorbidities, clinical signs and symptoms, laboratory tests, radiographic findings, treatment, and final outcomes were all recorded. Factors associated with severe disease requiring ICU admission were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Ninety subjects (82.5%) had laboratory-confirmed 2009 influenza A (H1N1). Sixty-four percent of these subjects had pneumonia on admission, 26% had respiratory failure, and 11% required care in the ICU. Dyspnea and the presence of infiltrates on chest x-rays were the most common signs among the subjects with H1N1. All subjects were treated with antiviral therapy, and 75% received antibiotic treatment based on their clinical and laboratory findings. The predictive factors of ICU admission were severe hypoxemia and lymphocytosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The outcome of subjects with influenza A (H1N1) virus infection was influenced by the severity of the disease on admission, the subjects' underlying conditions, and complications during hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.03049","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T09:18:33Z","timestamp":1407921513000},"page":"1560-1568","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Subjects Hospitalized With the 2009 Pandemic Influenza A (H1N1) Virus in a Respiratory Infection Unit: Clinical Factors Correlating With ICU Admission"],"prefix":"10.1177","volume":"59","author":[{"given":"Nikoletta","family":"Rovina","sequence":"first","affiliation":[{"name":"Intensive Care Unit, First Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and \u201cSotiria\u201d Chest Diseases Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalini","family":"Erifaki","sequence":"additional","affiliation":[{"name":"First Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and \u201cSotiria\u201d Chest Diseases Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevi","family":"Katsaounou","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Intensive Care Medicine, Evaggelismos Hospital, Medical School, University of Athens, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Lyxi","sequence":"additional","affiliation":[{"name":"First Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and \u201cSotiria\u201d Chest Diseases Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Koutsoukou","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, First Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and \u201cSotiria\u201d Chest Diseases Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos G","family":"Koulouris","sequence":"additional","affiliation":[{"name":"First Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and \u201cSotiria\u201d Chest Diseases Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manos","family":"Alchanatis","sequence":"additional","affiliation":[{"name":"First Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and \u201cSotiria\u201d Chest Diseases Hospital, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Disease Control and Prevention. 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