{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:53Z","timestamp":1791295373018,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Ventilation with low tidal volume is recommended for patients with acute lung injury. Current guidelines suggest limiting plateau pressure (P\n                      <jats:sub>plat<\/jats:sub>\n                      ) to &lt; 30 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O for septic patients needing mechanical ventilation. The aim of this study was to determine whether P\n                      <jats:sub>plat<\/jats:sub>\n                      within the first 24 h of ICU admission is predictive of outcome and whether P\n                      <jats:sub>plat<\/jats:sub>\n                      &lt; 30 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O is associated with lower mortality rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This study was a retrospective analysis of prospectively acquired clinical data from an ICU of a tertiary referral hospital in central Taiwan. Subjects were included if they were admitted due to sepsis and respiratory failure requiring mechanical ventilation from April 2008 to November 2009.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      There were 220 subjects (188 males, 32 females) with a median age of 76 y and a mean Acute Physiology and Chronic Health Evaluation II score of 25.0 \u00b1 6.5. Pneumonia was the major cause of sepsis (85.5%). The hospital mortality rate was 39.1%. P\n                      <jats:sub>plat<\/jats:sub>\n                      was higher throughout the first 24 h of ICU admission in nonsurvivors. Higher P\n                      <jats:sub>plat<\/jats:sub>\n                      was associated with higher mortality rates regardless of acute lung injury. In multivariate regression analysis, P\n                      <jats:sub>plat<\/jats:sub>\n                      &gt; 25 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O at 24 h after admission was an independent risk factor for mortality (adjusted odds ratio of 2.33, 95% CI 1.10\u20134.91,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03 for hospital mortality).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      P\n                      <jats:sub>plat<\/jats:sub>\n                      within the first 24 h of ICU admission is predictive of outcome, with lower P\n                      <jats:sub>plat<\/jats:sub>\n                      associated with lower mortality rates. There is no safety margin for P\n                      <jats:sub>plat<\/jats:sub>\n                      . Limiting P\n                      <jats:sub>plat<\/jats:sub>\n                      should be considered even at &lt; 30 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O in septic patients with acute respiratory failure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.03138","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T23:33:30Z","timestamp":1411515210000},"page":"12-20","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic Value of Plateau Pressure Below 30 cm H\n                    <sub>2<\/sub>\n                    O in Septic Subjects With Acute Respiratory Failure"],"prefix":"10.1177","volume":"60","author":[{"given":"Ming-Cheng","family":"Chan","sequence":"first","affiliation":[{"name":"Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan."},{"name":"Division of Chest Medicine"},{"name":"Central Taiwan University of Science and Technology, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Sen","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine"},{"name":"Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Te","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Hsuan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Critical Care and Respiratory Therapy, Department of Internal Medicine"},{"name":"Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sou-Jen","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Nursing, Taichung Veterans General Hospital, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Yuan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Nursing, Taichung Veterans General Hospital, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Liang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Critical Care and Respiratory Therapy, Department of Internal Medicine"},{"name":"Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Chiayi Branch, Chiayi, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Ru","family":"Kou","sequence":"additional","affiliation":[{"name":"Institute of Physiology, School of Medicine, National Yang-Ming 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