{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:50:54Z","timestamp":1777891854539,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>High-frequency pressure oscillations created by gas bubbling through an underwater seal during bubble CPAP may enhance ventilation and aid in lung recruitment in premature infants. We hypothesized that there are no differences in the magnitude of oscillations in lung volume (\u0394V) in a preterm neonatal lung model when different bubble CPAP systems are used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      An anatomically realistic replica of an infant nasal airway model was attached to a Silastic test lung sealed within a calibrated plethysmograph. Nasal prongs were affixed to the simulated neonate and supported using bubble CPAP systems set at 6 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O. \u0394V was calculated using pressure measurements obtained from the plethysmograph.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The Fisher &amp; Paykel Healthcare bubble CPAP system provided greater \u0394V than any of the other devices at all of the respective bias flows (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). The Fisher &amp; Paykel Healthcare and Babi.Plus systems generally provided \u0394V at lower frequencies than the other bubble CPAP systems. The magnitude of \u0394V increased at bias flows of &gt; 4 L\/min in the Fisher &amp; Paykel Healthcare, Airways Development, and homemade systems, but appeared to decrease as bias flow increased with the Babi.Plus system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The major finding of this study is that bubble CPAP can provide measureable ventilation effects in an infant lung model. We speculate that the differences noted in \u0394V between the different devices are a combination of the circuit\/nasal prong configuration, bubbler configuration, and frequency of oscillations. Additional testing is needed in spontaneously breathing infants to determine whether a physiologic benefit exists when using the different bubble CPAP systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.03432","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T21:59:21Z","timestamp":1416952761000},"page":"371-381","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Volume Oscillations Delivered to a Lung Model Using 4 Different Bubble CPAP Systems"],"prefix":"10.1177","volume":"60","author":[{"given":"Jonathan A","family":"Poli","sequence":"first","affiliation":[{"name":"Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Peter","family":"Richardson","sequence":"additional","affiliation":[{"name":"Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute, Seattle, Washington."},{"name":"University of Washington School of Medicine, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M","family":"DiBlasi","sequence":"additional","affiliation":[{"name":"Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute, Seattle, Washington."},{"name":"Respiratory Care Department, Children's Hospital and Regional Medical Center, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09541209"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200609-1368OC"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000013962"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0572-L"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000157721.66812.07"},{"key":"e_1_3_3_7_2","first-page":"86","article-title":"The use of bubble CPAP in preterm infants: local experience","volume":"12","author":"Chan KM","year":"2007","unstructured":"Chan KM, , Chan HB. The use of bubble CPAP in preterm infants: local experience. HK J Pediatr, 2007; 12:86\u201392.","journal-title":"HK J Pediatr"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ANC.0000317256.76201.72"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80425-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02322"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318123f702"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2012.08.013"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.55"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.12.034"},{"issue":"2","key":"e_1_3_3_15_2","first-page":"151","article-title":"Bubble-CPAP vs. ventilatory-CPAP in preterm infants with respiratory distress","volume":"21","author":"Bahman-Bijari B","year":"2011","unstructured":"Bahman-Bijari B, , Malekiyan A, , Niknafs P, , Baneshi MR. Bubble-CPAP vs. ventilatory-CPAP in preterm infants with respiratory distress. Iran J Pediatr, 2011; 21(2):151\u2013158.","journal-title":"Iran J Pediatr"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.12.054"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/30130"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2010155"},{"issue":"5","key":"e_1_3_3_19_2","first-page":"1329","article-title":"Design of a new variable-ventilation method optimized for lung recruitment in mice","volume":"104","author":"Thammanomai A","year":"2008","unstructured":"Thammanomai A, , Hueser LE, , Majumdar A, , Bartol\u00e1k-Suki E, , Suki B. Design of a new variable-ventilation method optimized for lung recruitment in mice. J Appl Phyisol, 2008; 104(5):1329\u20131340.","journal-title":"J Appl Phyisol"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-152PP"},{"key":"e_1_3_3_21_2","volume-title":"2013 AAP National Conference and Exhibition","author":"Goldstein MR","unstructured":"Goldstein MR, , Tong C, , Merritt TA, , Terry M, , Tiras M, , Fayard E, , Peverini R. Can the frequency of the vibratory waveform transmitted by bubble CPAP be used to calculate lung compliance (abstract)? 2013 AAP National Conference and Exhibition. https:\/\/aap.confex.com\/aap\/2013\/webprogram\/Paper22095.html. 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