{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:51:11Z","timestamp":1777891871243,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Noninvasive ventilation (NIV) in preterm infants is currently applied using intermittent positive pressure (2 positive-pressure levels) or in a conventional manner (one pressure level). However, there are no studies in the literature comparing the chances of failure of these NIV methods. The aim of this study was to evaluate the occurrence of failure of 2 noninvasive ventilatory support systems in preterm neonates over a period of 48 h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A randomized, prospective, clinical study was conducted on 80 newborns (gestational age &lt; 37 weeks, birthweight &lt; 2,500 g). The infants were randomized into 2 groups: 40 infants were treated with nasal CPAP and 40 infants with nasal intermittent positive-pressure ventilation (NIPPV). The occurrence of apnea, progression of respiratory distress, nose bleeding, and agitation was defined as ventilation failure. The need for intubation and re-intubation after failure was also observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in birth characteristics between groups. Ventilatory support failure was observed in 25 (62.5%) newborns treated with nasal CPAP and in 12 (30%) newborns treated with NIPPV, indicating an association between NIV failure and the absence of intermittent positive pressure (odds ratio [OR] 1.22,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). Apnea (32.5%) was the main reason for nasal CPAP failure. After failure, 25% (OR 0.33) of the newborns receiving nasal CPAP and 12.5% (OR 0.14) receiving NIPPV required invasive mechanical ventilation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Ventilatory support failure was significantly more frequent when nasal CPAP was used.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.03565","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T21:53:53Z","timestamp":1442354033000},"page":"1772-1776","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Response of Preterm Infants to 2 Noninvasive Ventilatory Support Systems: Nasal CPAP and Nasal Intermittent Positive-Pressure Ventilation"],"prefix":"10.1177","volume":"60","author":[{"given":"Carmen Salum Thom\u00e9","family":"Silveira","sequence":"first","affiliation":[{"name":"Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila Maia","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Physiotherapy, Hospital Santa Casa de Franca, Franca, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Carvalho Freire","family":"Melo","sequence":"additional","affiliation":[{"name":"Physiotherapy, Hospital Santa Casa de Franca, Franca, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eduardo","family":"Zaia","sequence":"additional","affiliation":[{"name":"Program in Health Promotion, University of Franca, Franca, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa Afonso Andrade","family":"Brunherotti","sequence":"additional","affiliation":[{"name":"Program in Health Promotion, University of Franca, Franca, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"CD003212","article-title":"Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation","volume":"9","author":"Lemyre B","year":"2014","unstructured":"Lemyre B, , Davis PG, , De Paoli AG, , Kirpalani H. Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation. Cochrane Database Syst Rev, 2014; 9:CD003212.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2007.02525.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.08.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1302"},{"issue":"7","key":"e_1_3_2_6_2","first-page":"524","article-title":"Randomized trial of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome","volume":"12","author":"Gao WW","year":"2010","unstructured":"Gao WW, , Tan SZ, , Chen YB, , Zhang Y, , Wang Y. Randomized trial of nasal synchronized intermittent mandatory ventilation compared with nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome. Zhongguo Dang Dai Er Ke Za Zhi, 2010; 12(7):524\u2013526. Article in Chinese.","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"issue":"1","key":"e_1_3_2_7_2","first-page":"CD002272","article-title":"Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for apnea of prematurity","volume":"1","author":"Lemyre B","year":"2002","unstructured":"Lemyre B, , Davis PG, , De Paoli AG. Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for apnea of prematurity. Cochrane Database Syst Rev, 2002; 1(1):CD002272.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1142"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214533"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211805"},{"key":"e_1_3_2_11_2","first-page":"1","volume-title":"Assisted ventilation of the neonate","author":"Goldsmith JP","year":"1996","unstructured":"Goldsmith JP, , Karotkin EH. Introduction to assisted ventilation. In: Goldsmith JP, , Karotkin EH, editors. Assisted ventilation of the neonate, 3rd edition. Philadelphia: WB Saunders; 1996; 1\u201319.","edition":"3"},{"key":"e_1_3_2_12_2","volume-title":"Noninvasive ventilation in neonatology and pediatrics, volume 1: pediatric and neonatal intensive care series","author":"Johnston C","year":"2007","unstructured":"Johnston C, , Melo DAS, , Carvalho WB. Initial parameters for the application of NIPPV. In: De Carvalho WB, , Johnston C, , Barbosa AP, editors. Noninvasive ventilation in neonatology and pediatrics, volume 1: pediatric and neonatal intensive care series. S\u00e3o Paulo: Editora Atheneu; 2007."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.223"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.069351"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.125"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2006.12.008"},{"issue":"2","key":"e_1_3_2_17_2","first-page":"91","article-title":"A comparison of nasal intermittent versus continuous positive pressure delivery for the treatment of moderate respiratory syndrome in preterm infants","volume":"59","author":"Bisceglia M","year":"2007","unstructured":"Bisceglia M, , Belcastro A, , Poerio V, , Raimondi F, , Mesuraca L, , Crugliano C, , Corapi UP. A comparison of nasal intermittent versus continuous positive pressure delivery for the treatment of moderate respiratory syndrome in preterm infants. Minerva Pediatr, 2007; 59(2):91\u201395.","journal-title":"Minerva Pediatr"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.117614"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.01.032"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.148981"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.03565","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.03565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.03565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:13:05Z","timestamp":1777615985000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.03565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.4187\/respcare.03565"],"URL":"https:\/\/doi.org\/10.4187\/respcare.03565","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}