{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:06:42Z","timestamp":1791320802501,"version":"4.3.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>In vivo deposition studies of aerosol administration during noninvasive ventilation (NIV) are scarce in the literature. The aim of this study was to compare radioaerosol pulmonary index and radioaerosol mass balance in the different compartments (pulmonary and extrapulmonary) of radio-tagged aerosol administered using vibrating mesh nebulizers and conventional jet nebulizers during NIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      This was a crossover clinical trial involving 10 healthy subjects (mean age of 33.7 \u00b1 10.0 y) randomly assigned to both treatment arms of this study: group 1 (NIV + vibrating mesh nebulizer,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10) and group 2 (NIV + jet nebulizer,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10). All subjects inhaled 3 mL of technetium-99m diethylenetriaminepentaacetic acid (25 mCi) and 0.9% saline solution via vibrating mesh and jet nebulizers during NIV through a face mask secured with straps while receiving positive inspiratory and expiratory pressures of 12 and 5 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O, respectively. Scintigraphy was performed to count radioaerosol particles deposited in the regions of interest to determine radioaerosol mass balance from the lungs, upper airways, stomach, nebulizer, ventilator circuit, inspiratory and expiratory filters, and mask as a percentage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Vibrating mesh nebulizers deposited 972,013 \u00b1 214,459 counts versus jet nebulizer with 386,025 \u00b1 130,363 counts (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005). In a determination of mass balance, vibrating mesh nebulizers showed a higher deposition of inhaled radioaerosol compared with jet nebulizers (23.1 \u00b1 5.8% vs 6.1 \u00b1 2.5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005) and a higher proportion of radioaerosol deposited into the lungs (5.5 \u00b1 0.9% versus 1.5 \u00b1 0.6%, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005). The residual drug volume was lower with vibrating mesh nebulizers (5.1 \u00b1 1.5%) compared with jet nebulizers (41.3 \u00b1 4.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>During NIV in healthy subjects, vibrating mesh nebulizers delivered &gt; 2-fold more radiolabeled drug into the respiratory tract compared with conventional jet nebulizers. Additional studies are recommended in subjects with asthma, COPD, bronchiectasis, and cystic fibrosis to better understand differences in both aerosol delivery and response. (ClinicalTrials.gov registration NCT01889524.)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.03667","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T21:15:27Z","timestamp":1435094127000},"page":"1238-1246","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Radioaerosol Pulmonary Deposition Using Mesh and Jet Nebulizers During Noninvasive Ventilation in Healthy Subjects"],"prefix":"10.1177","volume":"60","author":[{"given":"Valdecir C","family":"Galindo-Filho","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Universidade Federal de Pernambuco, Recife City, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eveline","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Universidade Federal de Pernambuco, Recife City, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina SF","family":"Rattes","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Universidade Federal de Pernambuco, Recife City, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio K","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital das Cl\u00ednicas de Pernambuco, Recife City, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella C","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Universidade Federal de Pernambuco, Recife City, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Cristina S","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital das Cl\u00ednicas de Pernambuco, Recife City, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Fink","sequence":"additional","affiliation":[{"name":"Division of Respiratory Therapy, School of Health Professions, Georgia State University, Atlanta, Georgia, Rush University Medical Center, Chicago, Illinois, and James B Fink LLC, San Mateo, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arm\u00e8le","family":"Dornelas de Andrade","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Universidade Federal de Pernambuco, Recife City, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05500367"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.5.8173743"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.4.1018"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04490653"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0429"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/02770900902718829"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01371"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000045563.64187.20"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09540071"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01134.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2011.0936"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2011.0929"},{"issue":"5","key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2223\/JPED.1070","article-title":"[Metered-dose inhalers with home-made spacers versus nebulizers to treat moderate wheezing attacks in children]","volume":"79","author":"Vilarinho LC","year":"2003","unstructured":"Vilarinho LC, , Cardeal Mendes CM, , de Freitas Souza LS. 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