{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:51:24Z","timestamp":1777891884306,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Studies suggest an effect of nebulized hypertonic saline solution on air-flow limitation in subjects with respiratory syncytial virus (RSV) bronchiolitis, but results are based on subjective scores of clinical severity and are not clear. In this observational study, we used a noninvasive computerized tool to quantify wheezing before and after nebulization with hypertonic saline in children admitted for RSV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Twenty-seven children (\u2264 24 months old) admitted to the pediatric ward of the Medical Center Leeuwarden with polymerase chain reaction-confirmed RSV bronchiolitis were included. Subjects were simultaneously assessed both clinically and by computerized acoustic monitoring before and 15 min after treatment with nebulized hypertonic saline solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Clinical assessment, defined by the Respiratory Distress Assessment Instrument score, did not change after nebulization (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 27, 5.0 vs 4.7,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .17). Computerized acoustic monitoring showed no improvement in wheezing (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 27, 3.4% vs 2.0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .05) or inspiration\/expiration ratio (0.85 vs 0.85,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .93) after nebulization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Hypertonic saline nebulization does not improve air flow, as assessed by both clinical and computerized acoustic scores, in children admitted for RSV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.03754","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T23:01:31Z","timestamp":1430262091000},"page":"1252-1256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Computerized Assessment of Wheezing in Children With Respiratory Syncytial Virus Bronchiolitis Before and After Hypertonic Saline Nebulization"],"prefix":"10.1177","volume":"60","author":[{"given":"Tina E","family":"Faber","sequence":"first","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvid WA","family":"Kamps","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machtelt H","family":"Sjoerdsma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nic JGM","family":"Veeger","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, MCL Academy, Medical Center Leeuwarden, Leeuwarden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J","family":"Bont","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050798"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00166508"},{"key":"e_1_3_2_4_2","first-page":"CD001266","article-title":"Bronchodilators for bronchiolitis","volume":"6","author":"Gadomski AM","year":"2014","unstructured":"Gadomski AM, , Scribani MB. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev, 2014; 6:CD001266.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_5_2","first-page":"CD004878","article-title":"Glucocorticoids for acute viral bronchiolitis in infants and young children","volume":"6","author":"Fernandes RM","year":"2013","unstructured":"Fernandes RM, , Bialy LM, , Vandermeer B, , Tjosvold L, , Plint AC, , Patel H, et al. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev, 2013; 6:CD004878.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900544"},{"key":"e_1_3_2_7_2","first-page":"CD006458","article-title":"Nebulised hypertonic saline solution for acute bronchiolitis in infants","volume":"7","author":"Zhang L","year":"2013","unstructured":"Zhang L, , Mendoza-Sassi RA, , Wainwright C, , Klassen TP. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev, 2013; 7:CD006458.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.5306"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21185"},{"issue":"12","key":"e_1_3_2_10_2","first-page":"1405","article-title":"Respirosonography in infants with acute bronchiolitis","volume":"145","author":"Tal A","year":"1991","unstructured":"Tal A, , Sanchez I, , Pasterkamp H. Respirosonography in infants with acute bronchiolitis. Am J Dis Child, 1991; 145(12):1405\u20131410.","journal-title":"Am J Dis Child"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-257"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-6-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00036302"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08531304"},{"issue":"7","key":"e_1_3_2_15_2","first-page":"760","article-title":"Acoustic analysis of wheezing in infants with acute bronchial obstruction","volume":"130","author":"S\u00e1nchez I","year":"2002","unstructured":"S\u00e1nchez I, , Navarro H, , Bertrand P, , Alvarez C, , Lisboa C. Acoustic analysis of wheezing in infants with acute bronchial obstruction. Rev Med Chil, 2002; 130(7):760\u2013767.","journal-title":"Rev Med Chil"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-7-22"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2742"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21108"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.04.010"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03304.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.2.481"},{"issue":"77","key":"e_1_3_2_22_2","first-page":"597","article-title":"Definition of terms for application of respiratory sounds","volume":"10","author":"Sovijarvi ARA","year":"2000","unstructured":"Sovijarvi ARA, , Dalmasso F, , Vanderschoot J, , Malmberg LP, , Righini G, , Stoneman SAT. Definition of terms for application of respiratory sounds. Eur Respir Rev, 2000; 10(77):597\u2013610.","journal-title":"Eur Respir Rev"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70342-1"},{"issue":"5","key":"e_1_3_2_24_2","first-page":"336","article-title":"Respiratory syncytial virus infection in young Malaysian children","volume":"40","author":"Chan P","year":"1999","unstructured":"Chan P, , Goh A. Respiratory syncytial virus infection in young Malaysian children. Singapore Med J, 1999; 40(5):336\u2013340.","journal-title":"Singapore Med J"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.196"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.1.2008090"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.03754","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.03754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.03754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:13:44Z","timestamp":1777616024000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.03754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.4187\/respcare.03754"],"URL":"https:\/\/doi.org\/10.4187\/respcare.03754","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}