{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:58:28Z","timestamp":1788832708801,"version":"build-2803163510"},"reference-count":46,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>A low serum vitamin D level may represent a marker of other perplexing factors that may lead to increased asthma prevalence and severity. Our aim was to assess the correlation between vitamin D levels and asthma and allergy markers in a subgroup of children with fewer confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Non-obese children (6\u201318 y old) with asthma who were not receiving anti-inflammatory treatment were recruited. Subjects underwent spirometry with a methacholine challenge test, and fractional exhaled nitric oxide (F\n                      <jats:sub>ENO<\/jats:sub>\n                      ), serum vitamin D levels, total immunoglobulin E (IgE) levels, blood eosinophil counts, and high-sensitivity C-reactive protein levels were determined. The primary end point was the correlation between vitamin D level and airway hyper-responsiveness as assessed by a methacholine challenge test. The secondary end point was the correlation between vitamin D level and F\n                      <jats:sub>ENO<\/jats:sub>\n                      , systemic inflammatory markers, and allergy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Seventy-one children with asthma (25 females, 35%; 12.5 \u00b1 3.6 y of age) were included. The median vitamin D level was 23 ng\/mL (range of 6\u201348.5, mean of 23.02 \u00b1 7.74), the median IgE level was 305 IU\/mL (range of 4.3\u20134,240), the median provocational concentration of methacholine that produced a 20% decrease in FEV\n                      <jats:sub>1<\/jats:sub>\n                      was 1.1 mg\/mL (range of 0\u201313.9), and the median F\n                      <jats:sub>ENO<\/jats:sub>\n                      was 26.5 ppb (range of 3.6\u2013285). No correlation was found between vitamin D level and response to the methacholine challenge test, F\n                      <jats:sub>ENO<\/jats:sub>\n                      , high-sensitivity C-reactive protein levels, IgE levels, eosinophil counts, and frequency of allergic rhinitis or atopic dermatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In our group of children with asthma, no correlation was found between the level of vitamin D and the degree of airway reactivity, airway inflammation, and allergy. The cause-and-effect relationship between vitamin D, asthma, and allergy should be further clarified. (ClinicalTrials.gov registration NCT01287455)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.03763","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T22:52:01Z","timestamp":1429656721000},"page":"1157-1163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma"],"prefix":"10.1177","volume":"60","author":[{"given":"Husein","family":"Dabbah","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Galilee Medical Center, Nahariya, Israel, and the Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Bar Yoseph","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Livnat","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahed","family":"Hakim","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Bentur","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel."},{"name":"Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000125"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205634"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2870"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00526.x"},{"issue":"8","key":"e_1_3_3_6_2","first-page":"1","article-title":"National surveillance for asthma\u2013United States, 1980-2004","volume":"56","author":"Moorman JE","year":"2007","unstructured":"Moorman JE, , Rudd RA, , Johnson CA, , King M, , Minor P, , Bailey C, et al. 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