{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:01:59Z","timestamp":1790485319108,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2016,1]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n Measurement of P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n is vital in determining effective alveolar ventilation. However, obtaining capillary P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n by a skin prick of the earlobe is painful, and nocturnal measurements disturb sleep. End-expiratory measurement of P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n is also well established, but there is a low precision in predicting arterial or capillary CO\n 2<\/jats:sub>\n . The purpose of the study was to evaluate nocturnal measurement of noninvasive, transcutaneous P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n (P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n ) measurement in hypercapnic subjects.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n In this prospective study, 31 subjects with chronic hypercapnic failure\u2014in a stable phase of the underlying disease\u2014and a control group of 12 healthy volunteers were included. Transcutaneous measurements were taken by the Tosca sensor (Radiometer, Copenhagen, Denmark) over a period of at least 6 h during the night. A capillary blood gas was measured at midnight and 4:00 am.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n The mean nocturnal capillary P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n (P\n \n capCO\n 2<\/jats:sub>\n <\/jats:sub>\n ) of subjects was 50.6 \u00b1 10.2 mm Hg. In the 31 subjects with known hypercapnic respiratory failure, the correlation between P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n and P\n \n capCO\n 2<\/jats:sub>\n <\/jats:sub>\n at midnight was 0.86 and at 4:00 am r = 0.80. The bias of the hypercapnic subjects was d = + 4.5 with a limit(s) of agreement of 2 SD = 13.0. The process of blood sampling caused no significant change in P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n Our study evaluated transcutaneous capnography as a continuous nocturnal measurement in hypercapnic subjects. We found a good agreement between the methods. Because CO\n 2<\/jats:sub>\n is not constant in patients with respiratory failure, but instead fluctuates, we would recommend the continuous transcutaneous measurement of P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n as our method of choice in the diagnosis of nocturnal hypercapnia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.03917","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T22:44:17Z","timestamp":1449009857000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of Transcutaneous and Capillary Measurement of P\n \n CO\n 2<\/sub>\n <\/sub>\n in Hypercapnic Subjects"],"prefix":"10.1177","volume":"61","author":[{"given":"Sven","family":"Stieglitz","sequence":"first","affiliation":[{"name":"Department of Pneumology and Cardiology, Petrus Hospital Wuppertal, Academic Teaching Hospital of the University of Duesseldorf, Wuppertal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Matthes","sequence":"additional","affiliation":[{"name":"Clinic for Pneumology and Allergology, Centre for Sleep and Ventilation Medicine, Bethanien Hospital, Institute of Pneumology, University Witten\/Herdecke, Solingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Priegnitz","sequence":"additional","affiliation":[{"name":"Clinic for Pneumology and Allergology, Centre for Sleep and Ventilation Medicine, Bethanien Hospital, Institute of Pneumology, University Witten\/Herdecke, Solingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hagmeyer","sequence":"additional","affiliation":[{"name":"Clinic for Pneumology and Allergology, Centre for Sleep and Ventilation Medicine, Bethanien Hospital, Institute of Pneumology, University Witten\/Herdecke, Solingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Randerath","sequence":"additional","affiliation":[{"name":"Clinic for Pneumology and Allergology, Centre for Sleep and Ventilation Medicine, Bethanien Hospital, Institute of Pneumology, University Witten\/Herdecke, Solingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"671","volume-title":"Textbook of respiratory medicine","author":"Gold W","year":"2000","unstructured":"Gold W. Pulmonary function testing. In: Murray J, , Nadel J, editors. Textbook of respiratory medicine; Vol. 1. Philadelphia: Elsevier, 2000; 671\u2013740."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.6.1443"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.4.364"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.07.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2011.02.001"},{"issue":"1","key":"e_1_3_3_7_2","first-page":"10","article-title":"Accuracy and precision of three different methods to determine Pco2 (Paco2 vs. Petco2 vs. Ptcco2) during interhospital ground transport of critically ill and ventilated adults","volume":"65","author":"Hinkelbein J","year":"2008","unstructured":"Hinkelbein J, , Floss F, , Denz C, , Krieter H. Accuracy and precision of three different methods to determine Pco2 (Paco2 vs. Petco2 vs. Ptcco2) during interhospital ground transport of critically ill and ventilated adults. J Trauma, 2008; 65(1):10\u201318.","journal-title":"J Trauma"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013040"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.04.011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.2.472"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2007.02273.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/3.3-4.269"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2334"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1291"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000181734.26070.26"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200007000-00011"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.3.768"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08531042"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0946"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00088005"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000295904"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000278642.16117.f8"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.4.1027"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31823d7784"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1978.tb01405.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.4.1117"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199406000-00016"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000178347.78420.7F"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.5.1211"},{"issue":"1","key":"e_1_3_3_31_2","first-page":"9","article-title":"An ambulatory system for long-term continuous monitoring of transcutaneous PCO2","volume":"23","author":"Pilsbury D","year":"1987","unstructured":"Pilsbury D, , Hibbert G. An ambulatory system for long-term continuous monitoring of transcutaneous PCO2. Bull Eur Physiopathol Respir, 1987; 23(1):9\u201313.","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.4.1079"},{"issue":"4","key":"e_1_3_3_33_2","first-page":"S89","article-title":"A comparison of end-tidal and transcutaneous PCO2 measurements during anaesthesia","volume":"37","author":"Reid CW","year":"1990","unstructured":"Reid CW, , Martineau RJ, , Miller DR, , Sullivan PJ, , Hull KA, , Samson B. A comparison of end-tidal and transcutaneous PCO2 measurements during anaesthesia. Can J Anaesth, 1990; 37(4 Pt 2):S89.","journal-title":"Can J Anaesth"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198412000-00013"},{"key":"e_1_3_3_35_2","first-page":"240","article-title":"Transcoutaneous PCO2 and end-tidal PCO2 in ventilated adults","volume":"37","author":"Blanchette T","year":"1992","unstructured":"Blanchette T, , Dzidzio J. Transcoutaneous PCO2 and end-tidal PCO2 in ventilated adults. Respir Care, 1992; 37:240\u2013248.","journal-title":"Respir Care"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236685"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198708000-00011"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.6.643"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02832145"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2011.02.008"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AACN.0000318125.41512.a3"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.03917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.03917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.03917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:14:23Z","timestamp":1777616063000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.03917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.4187\/respcare.03917"],"URL":"https:\/\/doi.org\/10.4187\/respcare.03917","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}