{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:53:14Z","timestamp":1777891994193,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2016,4]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n Transcutaneous carbon dioxide (P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n ) monitoring is being used increasingly to assess acute respiratory failure. However, there are conflicting findings concerning its reliability when evaluating patients with high levels of P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n . Our study evaluates the accuracy of this method in subjects with respiratory failure according to the severity of hypercapnia.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n We included subjects with respiratory failure, admitted to a respiratory intermediate care unit, who required arterial blood gas analysis. Simultaneously, P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n was measured using a digital monitor. Relations between P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n and P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n were assessed by the Pearson correlation coefficient. Bland-Altman analysis was used to test data dispersion, and an analysis of variance test was used to compare the differences between P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n and the corresponding P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n at different levels (level 1, <50 mm Hg; level 2, 50\u201360 mm Hg; level 3, >60 mm Hg).\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Eighty-one subjects were analyzed. The main diagnosis was COPD exacerbation (45%). P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n correlated well with P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n (r2 = 0.93,\n P<\/jats:italic>\n < .001). Bland-Altman analysis showed a mean P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n \u2212 P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n difference of 4.9 \u00b1 4.4 with 95% limits of agreement ranging from \u22123.6 to 13.4. The difference between variables increased in line with P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n severity: level 1, 1.7 \u00b1 3.2 mm Hg; level 2, 3.7 \u00b1 2.8; level 3, 6.8 \u00b1 4.7 (analysis of variance,\n P<\/jats:italic>\n < .001).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n Our study showed an acceptable agreement of P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n monitoring with arterial blood gas analysis. However, we should consider that P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n underestimates P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n levels, and its accuracy depends on the level of hypercapnia, so this method would not be suitable for acute patients with severe hypercapnia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.04283","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T22:58:53Z","timestamp":1453244333000},"page":"428-433","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Transcutaneous Carbon Dioxide Monitoring in Subjects With Acute Respiratory Failure and Severe Hypercapnia"],"prefix":"10.1177","volume":"61","author":[{"given":"Yolanda","family":"Ruiz","sequence":"first","affiliation":[{"name":"Respiratory Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Farrero","sequence":"additional","affiliation":[{"name":"Respiratory Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Respiratory Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Respiratory Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Dorca","sequence":"additional","affiliation":[{"name":"Respiratory Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Prats","sequence":"additional","affiliation":[{"name":"Respiratory Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0946"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1291"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.3.768"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.04987.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2012.03.033"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000181734.26070.26"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051664"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.84776"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.11.010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2076-1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2010.02213.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2007.055715"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1173"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1744"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1045"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-0006-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03335"},{"key":"e_1_3_3_19_2","first-page":"401","volume-title":"Principles and practice of intensive care monitoring","author":"Hanly PJ","year":"1994","unstructured":"Hanly PJ. Transcutaneous monitoring of carbon dioxide tension. In: Tobin M, editor. Principles and practice of intensive care monitoring. 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