{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:52:53Z","timestamp":1775469173273,"version":"3.50.1"},"reference-count":57,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,1]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n Endotracheal suctioning is required for mechanically ventilated patients to maintain a patent airway. Studies show that open endotracheal suctioning affects respiratory mechanics and gas exchange. The aim of this study was to compare the effectiveness of hyperoxygenation with F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n + 0.20 above baseline and hyperoxygenation with F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n 1.0 in preventing hypoxemia, and to determine the impact of open endotracheal suctioning on the pulmonary ventilation of critical subjects receiving mechanical ventilatory support.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n This prospective randomized crossover study was conducted in the ICU. Sixty-eight mechanically ventilated subjects with F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n \u2264 0.6 and requiring endotracheal suctioning were included in this study. Open endotracheal suctioning was performed using 2 different intervention sequences: hyperoxygenation of 0.20 above baseline F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n (F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n + 0.20) and 1.0 hyperoxygenation (F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n 1.0). Oxygenation was assessed via oxygen saturation as measured by pulse oximetry (S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n ), and changes in lung ventilation were measured via alveolar gas volume (V\u0307\n A<\/jats:sub>\n ), alveolar minute volume (V\u0307\n A min<\/jats:sub>\n ), carbon dioxide (CO\n 2<\/jats:sub>\n ) production (V\u0307\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n ), mixed exhaled partial pressure of CO\n 2<\/jats:sub>\n (P\n \n \u0304ECO\n 2<\/jats:sub>\n <\/jats:sub>\n ), exhaled tidal CO\n 2<\/jats:sub>\n volume (V\n T<\/jats:sub>\n CO\n 2<\/jats:sub>\n ), end-tidal CO\n 2<\/jats:sub>\n (P\n \n ETCO\n 2<\/jats:sub>\n <\/jats:sub>\n ), anatomical dead space to tidal volume ratio (V\n D<\/jats:sub>\n \/V\n T<\/jats:sub>\n ), and anatomical dead space volume of each breath (V\n D<\/jats:sub>\n ) using volumetric capnography, and breathing frequency (f), heart rate, and mean arterial pressure using a multiparameter monitor.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n levels were significantly higher within interventions (F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n + 0.20 and 1.0) 1 min before and after suction. Also, there was a significant increase in P\n \n ETCO\n 2<\/jats:sub>\n <\/jats:sub>\n , P\n \n \u0304ECO\n 2<\/jats:sub>\n <\/jats:sub>\n , heart rate, and mean arterial pressure immediately after the procedure compared with baseline, and in V\n T<\/jats:sub>\n CO\n 2<\/jats:sub>\n , only for F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n + 0.20. Baseline values were not found to be significantly different between the groups in case of any dependent variable.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n In mechanically ventilated adult subjects, hyperoxygenation with F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n + 0.20 above baseline prevents hypoxemia. Also, transient changes in pulmonary ventilation with open circuit suctioning were confirmed by volumetric capnography analysis. (Trial registration: ClinicalTrials.gov NCT02440919).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.04665","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T08:16:35Z","timestamp":1479284195000},"page":"92-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparing the Effects of Two Different Levels of Hyperoxygenation on Gas Exchange During Open Endotracheal Suctioning: A Randomized Crossover Study"],"prefix":"10.1177","volume":"62","author":[{"given":"Jacqueline Rodrigues de Freitas","family":"Vianna","sequence":"first","affiliation":[{"name":"Claretiano Centro Universit\u00e1rio, Santa Casa of Miseric\u00f3rdia Hospital, Batatais, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Amorim","family":"Pires Di Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Federal University of S\u00e3o Carlos, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mil\u00e9a Mara Louren\u00e7o da Silva","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Santa Casa of Miseric\u00f3rdia Hospital, Batatais, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio","family":"Jamami","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Federal University of S\u00e3o Carlos, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10550758"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02265"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.151020"},{"key":"e_1_3_3_5_2","unstructured":"Chaseling W Bayliss S-L Rose K Armstrong L Boyle M Caldwel J et al. 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