{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:31:33Z","timestamp":1787031093635,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Heated humidified high-flow nasal cannula (HFNC) is thought to be comparable with nasal CPAP. The effect of multimodality mid-level respiratory support use in the neonatal ICU is unknown. The objective of this work was to evaluate the effect of introducing HFNC on length of respiratory support and stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      A chart review was conducted on subjects at 24\u201332 weeks gestation requiring mid-level support (HFNC\/nasal CPAP) 1 y before and after HFNC implementation. The 2 groups were compared for clinical and demographic data using\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test or chi-square analysis. Further, multivariate linear and logistic regression was done to determine significant risk factors for outcomes controlling for covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Eighty subjects were eligible in the pre-HFNC group, and 83 were eligible in the post-HFNC group. Subjects were similar in their baseline characteristics. In clinical outcomes, the post-HFNC group had higher rates of retinopathy of prematurity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) and a trend toward higher bronchopulmonary dysplasia rates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .063). The post-HFNC subjects had longer duration of mid-level support and were older at the time they were weaned to stable low-flow nasal cannula (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). Although the length of respiratory support and stay and corrected gestational age at discharge were similar, those in the pre-HFNC period were more likely to be receiving full oral feeds and be discharged home versus being transferred to an intermediate care facility (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>HFNC introduction was significantly associated with a longer duration of mid-level respiratory support, decrease in oral feeding at discharge, increased retinopathy of prematurity rates, and higher use of intermediate care facilities, leading us to examine our noninvasive ventilation and weaning strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.04668","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T22:23:56Z","timestamp":1469571836000},"page":"1299-1304","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of High-Flow Nasal Cannula Use on Neonatal Respiratory Support Patterns and Length of Stay"],"prefix":"10.1177","volume":"61","author":[{"given":"Suma B","family":"Hoffman","sequence":"first","affiliation":[{"name":"University of Maryland School of Medicine, Department of Pediatrics, Baltimore Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Terrell","sequence":"additional","affiliation":[{"name":"University of Maryland Medical Center, Baltimore Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen Hughes","family":"Driscoll","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine, Department of Pediatrics, Baltimore Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine, Department of Pediatrics, Baltimore Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2541"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2012126"},{"issue":"2","key":"e_1_3_2_4_2","first-page":"CD000143","article-title":"Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants","author":"Davis PG","year":"2003","unstructured":"Davis PG, , Henderson-Smart DJ. Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants. Cochrane Database Syst Rev, 2003;(2):CD000143.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"e_1_3_2_5_2","first-page":"CD001243","article-title":"Prophylactic nasal continuous positive airways pressure for preventing morbidity and mortality in very preterm infants","author":"Subramaniam P","year":"2005","unstructured":"Subramaniam P, , Henderson-Smart DJ, , Davis PG. Prophylactic nasal continuous positive airways pressure for preventing morbidity and mortality in very preterm infants. 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