{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:25Z","timestamp":1790810905684,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Acute viral bronchiolitis is an inflammatory disease of the lower respiratory tract. This study aimed to compare the immediate effects of retrograde rhinopharyngeal clearance with nasopharyngeal aspiration in children admitted with acute viral bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This was a randomized controlled clinical trial with children admitted for acute viral bronchiolitis up to 12 months old. Subjects were divided into a nasopharyngeal aspiration group and a clearance group, submitted to retrograde rhinopharyngeal clearance with physiological solution (0.9%) instillation. In both groups, there were 3 evaluations on the same day (data collections 1, 2, and 3), including cardiorespiratory parameters, clinical score of respiratory dysfunction, and adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      One hundred children were included, with no statistical differences between groups regarding the characteristics of the sample. There was a significant reduction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05) in heart rate in data collections 1 and 2 after 10 and 30 min. The number of episodes of nasal bleeding (28 vs 1) and vomiting (11 vs 7) was higher in the aspiration group compared with the clearance group. Children classified as moderate showed a significant reduction of retractions (100% vs 84.6%) and nasal bleeding (44.8% vs 0%). An increase of 6.7 and 19.5% in wheezing and retractions, respectively, was shown for the aspiration group, whereas the clearance group showed only 4.6% for both parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The use of retrograde rhinopharyngeal clearance in the management of infants with acute viral bronchiolitis can be an alternative for the clearance of the upper airways, since it showed immediate positive effects on the occurrence of complications and signs of respiratory effort compared with nasopharyngeal aspiration. Children classified with a moderate clinical score appear to benefit the most. (ClinicalTrials.gov registration NCT02460614.)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.04685","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T22:49:44Z","timestamp":1471992584000},"page":"1613-1619","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Rhinopharyngeal Retrograde Clearance Induces Less Respiratory Effort and Fewer Adverse Effects in Comparison With Nasopharyngeal Aspiration in Infants With Acute Viral Bronchiolitis"],"prefix":"10.1177","volume":"61","author":[{"given":"Gabriela R","family":"Gomes","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda PG","family":"Calvete","sequence":"additional","affiliation":[{"name":"School of Nursing, Nutrition, and Physiotherapy, PUCRS, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela F","family":"Rosito","sequence":"additional","affiliation":[{"name":"School of Nursing, Nutrition, and Physiotherapy, PUCRS, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Vf","family":"Donadio","sequence":"additional","affiliation":[{"name":"Centro Infant, Institute of Biomedical Research, PUCRS, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2013.02.022"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2010.07.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2223"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2013.06.005"},{"issue":"2","key":"e_1_3_3_6_2","first-page":"CD004873","article-title":"Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old","author":"Roque i Figuls M","year":"2016","unstructured":"Roque i Figuls M, , Gine-Garriga M, , Granados Rugeles C, , Perrotta C, , Vilaro J. Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old. Cochrane Database Syst Rev, 2016;(2):CD004873.","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_3_3_7_2","first-page":"5","article-title":"[Chest physiotherapy and bronchiolitis in the hospitalised infant: double-blind clinical trial]","volume":"77","author":"S\u00e1nchez Bayle M","year":"2012","unstructured":"S\u00e1nchez Bayle M, , Mart\u00edn Mart\u00edn R, , Cano Fern\u00e1ndez J, , Mart\u00ednez S\u00e1nchez G, , G\u00f3mez Mart\u00edn J, , Yep Chullen G, , Garc\u00eda Garc\u00eda MC. [Chest physiotherapy and bronchiolitis in the hospitalised infant: double-blind clinical trial]. An Pediatr (Barc), 2012; 77(1):5\u201311.","journal-title":"An Pediatr (Barc)"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1562-y"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-35552012005000018"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-35552012005000120"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2013.11.007"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04491080"},{"issue":"2","key":"e_1_3_3_13_2","first-page":"135","article-title":"Abordagens fisioterap\u00eauticas para remo\u00e7\u00e3o de secre\u00e7\u00f5es das vias a\u00e9reas em rec\u00e9m-nascidos: relato de casos","volume":"28","author":"Haddad ER","year":"2006","unstructured":"Haddad ER, , da Costa LCD, , Negrini F, , Melosa LM. Abordagens fisioterap\u00eauticas para remo\u00e7\u00e3o de secre\u00e7\u00f5es das vias a\u00e9reas em rec\u00e9m-nascidos: relato de casos. Pediatria (S\u00e3o Paulo), 2006; 28(2):135\u2013140. Article in Portuguese.","journal-title":"Pediatria (S\u00e3o Paulo)"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1972.02110090097011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.00721"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132009000900007"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1755-7682-7-3"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000345"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(02)00268-3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9406(05)61230-8"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01890"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.60.11.1078"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-05822011000400020"},{"issue":"3","key":"e_1_3_3_24_2","first-page":"198","article-title":"[Indications of conventional chest physiotherapy in acute bronchiolitis]","volume":"64","author":"Boh\u00e9 L","year":"2004","unstructured":"Boh\u00e9 L, , Ferrero ME, , Cuestas E, , Polliotto L, , Genoff M. [Indications of conventional chest physiotherapy in acute bronchiolitis]. 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