{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:54:38Z","timestamp":1777892078193,"version":"3.51.4"},"reference-count":112,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    Traumatic brain injury is a problem that affects millions of Americans yearly and for which there is no definitive treatment that improves outcome. Continuous brain tissue oxygen (P\n                    <jats:sub>\n                      btO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    ) monitoring is a complement to traditional brain monitoring techniques, such as intracranial pressure and cerebral perfusion pressure. P\n                    <jats:sub>\n                      btO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    monitoring has not yet become a clinical standard of care, due to several unresolved questions. In this review, we discuss the rationale and technology of P\n                    <jats:sub>\n                      btO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    monitoring. We review the literature, both historic and current, and show that continuous P\n                    <jats:sub>\n                      btO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    monitoring is feasible and useful in patient management. P\n                    <jats:sub>\n                      btO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    numbers reflect cerebral blood flow and oxygen diffusion. Thus, continuous monitoring of P\n                    <jats:sub>\n                      btO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    yields important information about both the brain and the lung. The preclinical and clinical studies demonstrating these findings are discussed. In this review, we demonstrate that patient management in a P\n                    <jats:sub>\n                      btO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    -directed fashion is not the sole answer to the problem of treating traumatic brain injury but is an important adjunct to the armamentarium of multimodal neuromonitoring.\n                  <\/jats:p>","DOI":"10.4187\/respcare.04962","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T23:04:55Z","timestamp":1468969495000},"page":"1232-1244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Brain Tissue Oxygen Monitoring and the Intersection of Brain and Lung: A Comprehensive Review"],"prefix":"10.1177","volume":"61","author":[{"given":"Laura B","family":"Ngwenya","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco General Hospital, and the Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California 94110."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco General Hospital, and the Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California 94110."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey T","family":"Manley","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco, San Francisco General Hospital, and the Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California 94110."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2007-22502"},{"key":"e_1_3_2_3_2","unstructured":"Faul M Xu L Wald MM Coronado VG. 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