{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:07:38Z","timestamp":1789880858318,"version":"4.0.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Recent findings suggest that using alveolar P\n                      <jats:sub>\n                        CO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      (P\n                      <jats:sub>\n                        ACO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      ) estimated by volumetric capnography in the Bohr equation instead of P\n                      <jats:sub>\n                        aCO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      (Enghoff modification) could be appropriate for the calculation of physiological dead space to tidal volume ratio (V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Bohr<\/jats:sub>\n                      and V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Enghoff<\/jats:sub>\n                      , respectively). We aimed to describe the relationship between these 2 measurements in mechanically ventilated children and their significance in cases of ARDS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>From June 2013 to December 2013, mechanically ventilated children with various respiratory conditions were included in this study. Demographic data, medical history, and ventilatory parameters were recorded. Volumetric capnography indices (NM3 monitor) were obtained over a period of 5 min preceding a blood sample. Bohr's and Enghoff's dead space, S2 and S3 slopes, and the S2\/S3 ratio were calculated breath-by-breath using dedicated software (FlowTool). This study was approved by Ste-Justine research ethics review board.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Thirty-four subjects were analyzed. Mean V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Bohr<\/jats:sub>\n                      was 0.39 \u00b1 0.12, and V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Enghoff<\/jats:sub>\n                      was 0.47 \u00b1 0.13 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). The difference between V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Bohr<\/jats:sub>\n                      and V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Enghoff<\/jats:sub>\n                      was correlated with P\n                      <jats:sub>\n                        aO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      and with S2\/S3. In subjects without lung disease (P\n                      <jats:sub>\n                        aO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \u2265 300), mean V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Bohr<\/jats:sub>\n                      was 0.36 \u00b1 0.11, and V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Enghoff<\/jats:sub>\n                      was 0.39 \u00b1 0.11 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .056). Two children with status asthmaticus had a major difference between V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Bohr<\/jats:sub>\n                      and V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Enghoff<\/jats:sub>\n                      in the absence of a low P\n                      <jats:sub>\n                        aO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      This study suggests that V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Bohr<\/jats:sub>\n                      and V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T Enghoff<\/jats:sub>\n                      are not different when there is no hypoxemia (P\n                      <jats:sub>\n                        aO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      &gt; 300) except in the case of status asthmaticus. In subjects with a low P\n                      <jats:sub>\n                        aO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      , the method to measure V\n                      <jats:sub>D<\/jats:sub>\n                      \/V\n                      <jats:sub>T<\/jats:sub>\n                      must be reported, and results cannot be easily compared if the measurement methods are not the same.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.05108","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T20:10:40Z","timestamp":1487707840000},"page":"468-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of Bohr and Enghoff Dead Space Equations in Mechanically Ventilated Children"],"prefix":"10.1177","volume":"62","author":[{"given":"Pierre","family":"Bourgoin","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit, Hopital Femme-Enfant-Adolescent, Centre Hospitalier Universitaire de Nantes, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Baudin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brossier","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Emeriaud","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte-Justine and Pediatrics, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Universit\u00e9 de Montreal, Quebec, Canada, and GE Healthcare, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jouvet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte-Justine and the Division of Pediatric Critical Care Medicine, Department of Pediatrics, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1891.tb00581.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10550288"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc10324"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199905000-00032"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000287684.74505.49"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0371-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012835"},{"issue":"4","key":"e_1_3_3_9_2","first-page":"372","article-title":"Relationship between physiologic deadspace\/tidal volume ratio and gas exchange in infants with acute bronchiolitis on invasive mechanical ventilation","volume":"8","author":"Almeida-Junior AA","year":"2007","unstructured":"Almeida-Junior AA, , da Silva MT, , Almeida CC, , Ribeiro JD. 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