{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:53:21Z","timestamp":1775469201531,"version":"3.50.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Mid-frequency ventilation, a strategy of using conventional ventilators at high frequencies, may reduce lung injury but has had limited evaluation in neonates. Hence, a randomized crossover study was designed to assess the feasibility of using mid-frequency ventilation in preterm infants with respiratory distress syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Twelve preterm infants (\u2265500 g and \u226524 weeks gestational age) who were receiving pressure-limited conventional ventilation with frequencies \u226460 breaths\/min for respiratory distress syndrome were randomized to periods of mid-frequency ventilation (conventional ventilation with the fastest frequency up to 150 breaths\/min that gave complete inspiration and expiration) or conventional ventilation (frequency \u226460 breaths\/min), each lasting 2 h using a crossover design. Ventilator parameters were adjusted to maintain the O\n                      <jats:sub>2<\/jats:sub>\n                      saturation and transcutaneous CO\n                      <jats:sub>2<\/jats:sub>\n                      at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Mean peak inspiratory pressure (15 \u00b1 4 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O vs 18 \u00b1 4 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), \u0394 pressure (9.8 \u00b1 3.3 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O vs 13.5 \u00b1 3.9 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and tidal volume (2.6 \u00b1 0.4 mL\/kg vs 4.6 \u00b1 0.8 mL\/kg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) were lower, but mean airway pressure (8.9 \u00b1 1.9 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O vs 8.4 \u00b1 1.6 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) and measured PEEP (5.1 \u00b1 0.5 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O vs 4.4 \u00b1 0.5 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) were higher with mid-frequency compared with conventional ventilation. F\n                      <jats:sub>IO2<\/jats:sub>\n                      , gas exchange, and hemodynamic parameters were not affected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Based on this small study, mid-frequency ventilation among preterm infants with respiratory distress syndrome is feasible. Further larger and longer duration trials are necessary to validate our findings. (ClinicalTrials.gov registration NCT01242462)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.05157","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T20:40:18Z","timestamp":1483476018000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility of Mid-Frequency Ventilation Among Infants With Respiratory Distress Syndrome"],"prefix":"10.1177","volume":"62","author":[{"given":"Ramachandra","family":"Bhat","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kelleher","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namasivayam","family":"Ambalavanan","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L","family":"Chatburn","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Mireles-Cabodevila","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar A","family":"Carlo","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,4,1]]},"reference":[{"issue":"3","key":"e_1_3_2_2_2","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts D","year":"2006","unstructured":"Roberts D, , Dalziel S. 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