{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:54:16Z","timestamp":1775469256564,"version":"3.50.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Lung clearance index (LCI), a measure of ventilation inhomogeneity derived from a multiple-breath washout test, is a promising tool for assessing airway function in patients with non-cystic fibrosis bronchiectasis. However, it is unknown whether ventilation inhomogeneity could improve after successful elimination of excessive secretions within bronchiectasis. The objective of this work was to assess the short-term effects of lung secretion clearance using the autogenic drainage technique on standard lung function tests and LCI in subjects with non-cystic fibrosis bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Nitrogen-based multiple-breath washout, spirometry, and body plethysmography tests were performed 30 min before autogenic drainage in adults with stable non-cystic fibrosis bronchiectasis. The autogenic drainage session was followed by a 5-min break, after which the tests were repeated in the same order. Sputum expectorated during autogenic drainage was quantified as dry weight and correlated with change between post- and pre-measurements (\u0394). Paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test or Wilcoxon signed-rank tests were used to compare pre- and post-autogenic drainage measurement outcomes. A\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of \u2264.05 was considered as statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Twenty-four subjects were studied (18 females, median age [range]: 65 [21\u201381] y). Mean \u00b1 SD LCI significantly improved after autogenic drainage (10.88 \u00b1 2.62 vs 10.53 \u00b1 2.35,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .042). However, only 20% of subjects with mucus hyperproduction during autogenic drainage had a \u0394LCI that exceeded measurement variability. The percent of predicted slow vital capacity (SVC%) also slightly improved (88.7 \u00b1 19.3% vs 90 \u00b1 19.1%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). \u0394LCI was inversely related to dry sputum weight (r = \u2212.48,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) and \u0394SVC% (r = \u2212.64,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001). \u0394SVC% also correlated with dry sputum weight (r = 0.46,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In adults with non-cystic fibrosis bronchiectasis and mucus hypersecretion, autogenic drainage improved ventilation inhomogeneity. LCI change may be the result of the maximum recruited lung volume and the amount of cleared mucus secretion. (ClinicalTrials.gov registration NCT02411981.)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.05194","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T20:10:40Z","timestamp":1487707840000},"page":"524-531","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Short-Term Effect of Autogenic Drainage on Ventilation Inhomogeneity in Adult Subjects With Stable Non-Cystic Fibrosis Bronchiectasis"],"prefix":"10.1177","volume":"62","author":[{"given":"William","family":"Poncin","sequence":"first","affiliation":[{"name":"Department of Pneumology"},{"name":"Universit\u00e9 Catholique de Louvain (UCL), Institute of Experimental and Clinical Research, Pole of Pneumology, ENT, and Dermatology, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9gory","family":"Reychler","sequence":"additional","affiliation":[{"name":"Department of Pneumology"},{"name":"Department of Physical Medicine and Rehabilitation"},{"name":"Universit\u00e9 Catholique de Louvain (UCL), Institute of Experimental and Clinical Research, Pole of Pneumology, ENT, and Dermatology, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Leeuwerck","sequence":"additional","affiliation":[{"name":"Department of Pneumology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Bauwens","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation"},{"name":"Cystic Fibrosis Unit, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Aubriot","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation"},{"name":"Cystic Fibrosis Unit, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."},{"name":"Universit\u00e9 Catholique de Louvain (UCL), Institute of Experimental and Clinical Research, Pole of Pneumology, ENT, and Dermatology, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candice","family":"Nader","sequence":"additional","affiliation":[{"name":"Department of Pneumology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Liistro","sequence":"additional","affiliation":[{"name":"Department of Pneumology"},{"name":"Universit\u00e9 Catholique de Louvain (UCL), Institute of Experimental and Clinical Research, Pole of Pneumology, ENT, and Dermatology, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Gohy","sequence":"additional","affiliation":[{"name":"Department of Pneumology"},{"name":"Cystic Fibrosis Unit, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."},{"name":"Universit\u00e9 Catholique de Louvain (UCL), Institute of Experimental and Clinical Research, Pole of Pneumology, ENT, and Dermatology, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012519"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct109"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00003709"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0411CI"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"issue":"11","key":"e_1_3_3_7_2","first-page":"CD008351","article-title":"Airway clearance techniques for bronchiectasis","author":"Lee AL","year":"2015","unstructured":"Lee AL, , Burge AT, , Holland AE. 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