{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:54:58Z","timestamp":1775469298462,"version":"3.50.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n BACKGROUND:<\/jats:title>\n High-frequency jet ventilation (HFJV) has been used in conjunction with conventional ventilation for infants with respiratory failure. We sought to identify parameters that were associated with successful application of HFJV in patients with hypercapnic respiratory failure.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n A single-center, retrospective review of infants who received HFJV was conducted. Subjects were enrolled if birthweight was \u22642,000 g and capillary P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n was \u226555 mm Hg. Ventilator parameters and physiologic data were recorded at 1 h before HFJV initiation and at hours 1, 4, and 6 following conversion. Subjects were classified as responders if capillary P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n was reduced by \u226510% after 1 h of HFJV. Data included peak inspiratory pressure, PEEP, capillary P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n , and oxygen saturation index (equal to mean airway pressure \u00d7 F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n \u00d7 100\/S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n ). Because the data were not normally distributed, they are reported as median (interquartile range), and the Mann-Whitney test was used to assess differences in continuous data between groups. Categorical data were analyzed using a chi-square and Fisher exact test.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Thirty-four premature infants (\n n<\/jats:italic>\n = 24 male) were studied. Twenty-five subjects were classified as responders and demonstrated a significant reduction of capillary P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n and F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n and increased pH within the first hour. The non-responders demonstrated a higher conventional ventilation peak inspiratory pressure (25 cm H\n 2<\/jats:sub>\n O vs 19 cm H\n 2<\/jats:sub>\n O,\n P<\/jats:italic>\n = .005) and had a greater postmenstrual age (30 weeks vs 26.5 weeks,\n P<\/jats:italic>\n = .01). This group had a higher oxygen saturation index (7.25 vs 3.36,\n P<\/jats:italic>\n = .03) and F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n requirements (0.6 vs 0.35,\n P<\/jats:italic>\n = .038) at 4 h.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n We identified that lower postmenstrual age, improvements in capillary P\n \n CO\n 2<\/jats:sub>\n <\/jats:sub>\n and pH at 1 h, and a reduction of F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n were associated with good response to HFJV. These data may help to identify patients who are likely to benefit from HFJV in the neonatal intensive care unit.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.05264","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T20:13:17Z","timestamp":1491336797000},"page":"867-872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Assessing Initial Response to High-Frequency Jet Ventilation in Premature Infants With Hypercapnic Respiratory Failure"],"prefix":"10.1177","volume":"62","author":[{"given":"Craig R","family":"Wheeler","sequence":"first","affiliation":[{"name":"Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig D","family":"Smallwood","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts."},{"name":"Division of Critical Care Medicine, Department of Anesthesia, Preoperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gagner","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha C","family":"Sola-Visner","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.01.010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2006.12.004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60278-4"},{"issue":"3","key":"e_1_3_2_6_2","first-page":"CD000104","article-title":"Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants","author":"Cools F","year":"2009","unstructured":"Cools F, , Henderson-Smart DJ, , Offringa M, , Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev, 2009(3):CD000104.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.98.6.1035"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.4.593"},{"issue":"10","key":"e_1_3_2_9_2","first-page":"CD000437","article-title":"Rescue high-frequency jet ventilation versus conventional ventilation for severe pulmonary dysfunction in preterm infants","author":"Rojas-Reyes MX","year":"2015","unstructured":"Rojas-Reyes MX, , Orrego-Rojas PA. Rescue high-frequency jet ventilation versus conventional ventilation for severe pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev, 2015;(10):CD000437.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83548-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81046-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80173-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-954821"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.89.3.491"},{"issue":"1","key":"e_1_3_2_15_2","first-page":"3","article-title":"Controlled prospective randomized comparison of high-frequency jet ventilation and conventional ventilation in neonates with respiratory failure and persistent pulmonary hypertension","volume":"17","author":"Engle WA","year":"1997","unstructured":"Engle WA, , Yoder MC, , Andreoli SP, , Darragh RK, , Langefeld CD, , Hui SL. Controlled prospective randomized comparison of high-frequency jet ventilation and conventional ventilation in neonates with respiratory failure and persistent pulmonary hypertension. 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