{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:34:59Z","timestamp":1781793299588,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>A clinical classification system has been developed to define the severity and predict the prognosis of subjects with non-cystic fibrosis (CF) bronchiectasis. We aimed to identify laboratory parameters that are correlated with the bronchiectasis severity index (BSI) and FACED score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The medical records of 107 subjects with non-CF bronchiectasis for whom BSI and FACED scores could be calculated were retrospectively reviewed. The correlations between the laboratory parameters and BSI or FACED score were assessed, and multiple-linear regression analysis was performed to identify variables independently associated with BSI and FACED score. An additional subgroup analysis was performed according to sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Among all of the enrolled subjects, 49 (45.8%) were male and 58 (54.2%) were female. The mean BSI and FACED scores were 9.43 \u00b1 3.81 and 1.92 \u00b1 1.59, respectively. The serum albumin level (r = \u22120.49), bilirubin level (r = \u22120.31), C-reactive protein level (r = 0.22), hemoglobin level (r = \u22120.2), and platelet\/lymphocyte ratio (r = 0.31) were significantly correlated with BSI. Meanwhile, serum albumin (r = \u22120.37) and bilirubin level (r = \u22120.25) showed a significant correlation with the FACED score. Multiple-linear regression analysis showed that the serum bilirubin level was independently associated with BSI, and the serum albumin level was independently associated with both scoring systems. Subgroup analysis revealed that the level of uric acid was also a significant variable independently associated with the BSI in male bronchiectasis subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Several laboratory variables were identified as possible prognostic factors for non-CF bronchiectasis. Among them, the serum albumin level exhibited the strongest correlation and was identified as an independent variable associated with the BSI and FACED scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.05276","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T20:20:14Z","timestamp":1494966014000},"page":"1075-1084","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Serum Albumin and Disease Severity of Non-Cystic Fibrosis Bronchiectasis"],"prefix":"10.1177","volume":"62","author":[{"given":"Seung Jun","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunmi","family":"Ju","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujin","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Wan","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Jin","family":"Nam","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Dong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Seop","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rock Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Environmental Health Center, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Ji","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Yeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Deog","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Allergy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328312ed8c"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202893"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00026313"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1575OC"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Leung TF Ko FW Wong GW. Recent advances in asthma biomarker research: therapeutic advances in respiratory disease. 2013; 7(5):297\u2013308.","DOI":"10.1177\/1753465813496863"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-0871PP"},{"issue":"2","key":"e_1_3_2_9_2","first-page":"CD005603","article-title":"Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults","author":"Petsky HL","year":"2007","unstructured":"Petsky HL, , Kynaston JA, , Turner C, , Li AM, , Cates CJ, , Lasserson TJ, et al. Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev, 2007;(2):CD005603.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200411-1498OC"},{"issue":"3","key":"e_1_3_2_11_2","first-page":"180","article-title":"Biomarkers in airway diseases","volume":"20","author":"Leung JM","year":"2013","unstructured":"Leung JM, , Sin DD. Biomarkers in airway diseases. Can Respir J, 2013; 20(3):180\u2013182.","journal-title":"Can Respir J"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.983167"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201300108"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.2.7618537"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0167-9"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.02.002"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.012"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2004.01.011"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00003709"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01219.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00170014"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1518OC"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.12.015"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874306401509010046"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208481"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5732"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1579-2129(08)60003-8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/1479972312459973"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.5578\/tt.2934"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205271"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2011.579202"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.124"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2150"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0894-0959.2004.17603.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.596"},{"issue":"6","key":"e_1_3_2_39_2","first-page":"1322","article-title":"Association of nutritional status, plasma, albumin levels and pulmonary function in cystic fibrosis","volume":"26","author":"Souza dos Santos Simon MI","year":"2011","unstructured":"Souza dos Santos Simon MI, , Drehmer M, , de Abreu E Silva FA, , Hoffmann A, , Druck Ricachinewsky C, , de Fonseca Andrade Procianoy E, et al. Association of nutritional status, plasma, albumin levels and pulmonary function in cystic fibrosis. Nutr Hosp, 2011; 26(6):1322\u20131327.","journal-title":"Nutr Hosp"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S51467"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00024804"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S85831"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.05276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.05276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.05276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:55:33Z","timestamp":1775465733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.05276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.4187\/respcare.05276"],"URL":"https:\/\/doi.org\/10.4187\/respcare.05276","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5,16]]}}}