{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T05:17:27Z","timestamp":1780809447615,"version":"3.54.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n Limiting tidal volume (V\n T<\/jats:sub>\n ) in patients with ARDS may not be achieved once patient-triggered breaths occur. Furthermore, ICU ventilators offer numerous patient-triggered modes that work differently across brands. We systematically investigated, using a bench model, the effect of patient-triggered modes on the size and variability of V\n T<\/jats:sub>\n at different breathing frequencies (f), patient effort, and ARDS severity.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n We used a V500 Infinity ICU ventilator connected to an ASL 5000 lung model whose compliance was mimicking mild, moderate, and severe ARDS. Thirteen patient-triggered modes were tested, falling into 3 categories, namely volume control ventilation with mandatory minute ventilation; pressure control ventilation, including airway pressure release ventilation (APRV); and pressure support ventilation. Two levels of f and effort were tested for each ARDS severity in each mode. Median (first-third quartiles) V\n T<\/jats:sub>\n was compared across modes using non-parametric tests. The probability of V\n T<\/jats:sub>\n > 6 mL\/kg ideal body weight was assessed by binomial regression and expressed as the odds ratio (OR) with 95% CI. V\n T<\/jats:sub>\n variability was measured from the coefficient of variation.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n V\n T<\/jats:sub>\n distribution over all f, effort, and ARDS categories significantly differed across modes (\n P<\/jats:italic>\n < .001, Kruskal\u2013Wallis test). V\n T<\/jats:sub>\n was significantly greater with pressure support (OR 420 mL, 95% CI 332\u2013527 mL) than with any other mode except for variable pressure support level. Risk for V\n T<\/jats:sub>\n to be > 6 mL\/kg was significantly increased with spontaneous breaths patient-triggered by pressure support (OR 19.36, 95% CI 12.37\u201330.65) and significantly reduced in APRV (OR 0.44, 95% CI 0.26\u20130.72) and pressure support with guaranteed volume mode. The risk increased with increasing effort and decreasing f. Coefficient of variation of V\n T<\/jats:sub>\n was greater for low f and volume control-mandatory minute ventilation and pressure control modes. APRV had the greatest within-mode variability.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n Risk of V\n T<\/jats:sub>\n > 6 mL\/kg was significantly reduced in APRV and pressure support with guaranteed volume mode. APRV had the highest variability. Pressure support with guaranteed volume could be tested in patients with ARDS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.05415","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T20:40:38Z","timestamp":1501620038000},"page":"1437-1446","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Variability of Tidal Volume in Patient-Triggered Mechanical Ventilation in ARDS"],"prefix":"10.1177","volume":"62","author":[{"given":"Sophie","family":"Perinel-Ragey","sequence":"first","affiliation":[{"name":"R\u00e9animation M\u00e9dicale, H\u00f4pital de la Croix Rousse, Lyon, France."},{"name":"Universit\u00e9 de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Baboi","sequence":"additional","affiliation":[{"name":"R\u00e9animation M\u00e9dicale, H\u00f4pital de la Croix Rousse, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"R\u00e9animation M\u00e9dicale, H\u00f4pital de la Croix Rousse, Lyon, France."},{"name":"Universit\u00e9 de Lyon, Lyon, France."},{"name":"IMRB INSERM 955, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev028"},{"issue":"23","key":"e_1_3_3_5_2","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"ARDS definition Task force","year":"2012","unstructured":"ARDS definition Task force, Ranieri VM, , Rubenfeld GD, , Thompson BT, , Ferguson ND, , Caldwell E, et al. Acute respiratory distress syndrome: the Berlin definition. JAMA, 2012; 307(23):2526\u20132533.","journal-title":"JAMA"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2169OC"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753465815576439"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1081CP"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10550770"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182711972"},{"key":"e_1_3_3_11_2","article-title":"Volume controlled ventilation does not prevent injurious inflation during spontaneous effort","author":"Yoshida T","unstructured":"Yoshida T, , Nakahashi S, , Nakamura MA, , Koyama Y, , Roldan R, , Torsani V, et al. Volume controlled ventilation does not prevent injurious inflation during spontaneous effort. Am J Respir Crit Care Med. doi: 10.1164\/rccm.201610-1972OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3032-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0539OC"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422002"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2016.03.009"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1016OC"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.05415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.05415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.05415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:55:05Z","timestamp":1775465705000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.05415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.4187\/respcare.05415"],"URL":"https:\/\/doi.org\/10.4187\/respcare.05415","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8,1]]}}}