{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:44:43Z","timestamp":1791420283962,"version":"4.3.3"},"reference-count":24,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The objective of this work was to describe the use of negative-pressure ventilation (NPV) in a heterogeneous critically ill, pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A retrospective chart review was conducted of all patients admitted to a pediatric ICU with acute respiratory failure supported with NPV from January 1, 2012 to May 15, 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Two hundred thirty-three subjects at a median age of 15.5 months were supported with NPV for various etiologies, most commonly bronchiolitis (70%). Median (interquartile range) duration of support was 18.7 (8.7\u201334.3) h. The majority were NPV responders (70%), defined as not needing escalation to any form of positive-pressure ventilation. In non-responders, escalation occurred at a median (interquartile range) of 6.9 (3.3\u201316.6) h. More NPV non-responders had upper-airway obstruction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02), and fewer had bronchiolitis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .008) compared with responders. A bedside scoring system developed on these data was 98% specific in predicting NPV failure by 4 h after NPV start (area under the curve 0.759, 95% CI 0.675\u20130.843,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Complications from NPV were rare (3%); however, delayed enteral nutrition (33%) and continuous intravenous sedation use (51%) in children while receiving NPV were more frequent. The annual percentage of pediatric ICU admissions requiring intubation declined by 28% in the 3 y after NPV introduction, compared with the 3 y prior.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>NPV is a noninvasive respiratory support for pediatric acute respiratory failure from all causes with few complications and a 70% response rate. Children receiving NPV often required intravenous sedation for comfort, and one third received delayed enteral nutrition. Those who required escalation from NPV worsened within 6 h; this may be predictable with a bedside scoring system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.05531","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T20:25:24Z","timestamp":1504211124000},"page":"1540-1549","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Negative-Pressure Ventilation in Pediatric Acute Respiratory Failure"],"prefix":"10.1177","volume":"62","author":[{"given":"Amanda B","family":"Hassinger","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan K","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Nutty","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, Women and Children's Hospital of Buffalo, Buffalo, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Xing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and Health Professions University at Buffalo, Buffalo, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar S","family":"Al Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"issue":"10","key":"e_1_3_2_2_2","first-page":"622","article-title":"[Current concepts of weaning children from invasive ventilation]","volume":"48","author":"Fuchs H","year":"2013","unstructured":"Fuchs H, , Nicolai T, , Schmid MB, , Kr\u00fcger M. [Current concepts of weaning children from invasive ventilation]. Anasthesiol Intensivmed Notfallmed Schmerzther, 2013; 48(10):622\u2013625.","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/37264"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32801297f9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.5.418"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00302602"},{"issue":"4","key":"e_1_3_2_7_2","first-page":"297","article-title":"Continuous negative extrathoracic pressure in children after congenital heart surgery","volume":"8","author":"Shime N","year":"2006","unstructured":"Shime N, , Toida C, , Itoi T, , Hashimoto S. Continuous negative extrathoracic pressure in children after congenital heart surgery. 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Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children. 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Reversal of negative pressure ventilation-induced lower esophageal sphincter dysfunction with metoclopramide. 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