{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:46:41Z","timestamp":1790545601951,"version":"4.1.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Exercise intolerance is the most predominant symptom in patients with COPD. Nevertheless, it is unclear whether walking economy and gait variability are altered in these patients. Thus, our main objective was to compare the cost of transport and gait variability as a function of speed, including the self-selected walking speed, in subjects with COPD relative to healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      22 subjects, 11 with COPD (FEV\n                      <jats:sub>1<\/jats:sub>\n                      = 45 \u00b1 17% of predicted) and 11 age- and sex-matched healthy subjects undertook an evaluation that involved walking on a treadmill at 6 speeds (at 3.2 km\/h, at a self-selected walking speed, and at 2 speeds below and 2 speeds above the self-selected walking speed) and measuring the cost of transport (the oxygen consumption normalized by mass and distance), gait variability, perceived dyspnea, and leg fatigue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      In subjects with COPD, the cost of transport decreased with increasing walking speed, contrary to healthy subjects, who presented a minimum at the self-selected walking speed. No difference was found in cost of transport between the experimental groups at the same absolute velocity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .62). In subjects with COPD, dyspnea sensation rose above the self-selected walking speed, doubling at the maximal walking velocity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03), and gait variability was higher at low speeds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Subjects with COPD choose their walking speed so as to keep the dyspnea sensation tolerable and to keep gait variability and cost of transport at an acceptable level. These outcomes suggest that interventions acting on dyspnea and gait pattern may increase patients' self-selected walking speed and improve their quality of life<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.05768","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T20:40:33Z","timestamp":1511296833000},"page":"301-310","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Limiting Factors in Walking Performance of Subjects With COPD"],"prefix":"10.1177","volume":"63","author":[{"given":"Marcela Alves","family":"Sanseverino","sequence":"first","affiliation":[{"name":"Pathophysiology and Pulmonary Function Laboratory of Clinical Hospital of Porto Alegre."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pecchiari","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiopatologia e dei Trapianti, Universit\u00e0 degli Studi di Milano, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Luisa","family":"Bona","sequence":"additional","affiliation":[{"name":"Biomechanics Research and Movement Analyses Laboratory, CENUR Litoral Norte, Universidad de la Rep\u00fablica, Paysand\u00fa, Uruguay."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Cortozi","family":"Berton","sequence":"additional","affiliation":[{"name":"Pathophysiology and Pulmonary Function Laboratory of Clinical Hospital of Porto Alegre."},{"name":"Post-Graduate Program in Respiratory Sciences, Medical School, Universidade Federal do Rio Grande do Sul."},{"name":"Respiratory Division, Clinical Hospital of Porto Alegre."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Busolli","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"Pathophysiology and Pulmonary Function Laboratory of Clinical Hospital of Porto Alegre."},{"name":"Post-Graduate Program in Respiratory Sciences, Medical School, Universidade Federal do Rio Grande do Sul."},{"name":"Respiratory Division, Clinical Hospital of Porto Alegre."},{"name":"Exercise Research Laboratory, Universidade Federal do Rio Grande do Sul."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Gruet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulon, Universit\u00e9 C\u00f4te d'Azur, LAMHESS, Toulon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo A","family":"Peyr\u00e9-Tartaruga","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Respiratory Sciences, Medical School, Universidade Federal do Rio Grande do Sul."},{"name":"Exercise Research Laboratory, Universidade Federal do Rio Grande do Sul."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Global Strategy for Diagnosis Management and Prevention for Chronic Obstructive Pulmonary Diseases. www.goldcopd.org GOLD Report Dec 2015."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00379.2013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S49491"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2017"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90336.2008b"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90336.2008a"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90336.2008"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12129"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2006.01522.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318277968f"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0048-2016"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0054-2016"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.03.022"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2010.01.022"},{"issue":"6","key":"e_1_3_3_16_2","first-page":"677","article-title":"Are the spatio-temporal parameters of gait capable of distinguishing a faller from a non-faller elderly?","volume":"50","author":"Mortaza N","year":"2014","unstructured":"Mortaza N, , Abu Osman NA, , Mehdikhani N. 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