{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:43:32Z","timestamp":1787168612957,"version":"build-2736575974"},"reference-count":43,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Bench and clinical data indicate that techniques for applying noninvasive respiratory support may vary in terms of effectiveness, application, and tolerability. We implemented a new nasal interface and flow-generation system for the delivery of noninvasive respiratory support (NRS) to replace previously used systems. Our goal was to determine whether there were significant differences in clinically relevant outcomes between our new method and conventional systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective observational study of preterm infants requiring noninvasive respiratory support during our initial implementation of a new nasal interface (RAM), and compared these data with a historic control group. Demographic, baseline, and clinical outcome data were collected. Clinical outcomes and comorbid conditions were compared by using the chi-square test for categorical information and the Student\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test or Wilcoxon rank-sum test for quantitative data, depending on normality testing when using the Shapiro-Wilk test. Uni- and multivariate logistic regression were conducted to determine predictive factors for the development of bronchopulmonary dysplasia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      There were no significant group differences in important comorbid conditions, invasive mechanical ventilation days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .16), or NRS failure within the first 7 d after birth (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .10). Although there were no significant differences in the use of CPAP or noninvasive ventilation, settings with were significantly higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) in the RAM group. There were more incidences of retinopathy of prematurity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) post RAM implementation, and the time to first reintubation was significantly shorter in the RAM group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .044). However, there were significant reductions post RAM in total days on any respiratory support (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .009), total NRS days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02), and supplemental O\n                      <jats:sub>2<\/jats:sub>\n                      duration (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). There was a trend toward reductions in bronchopulmonary dysplasia rates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .053), and the incidence of device-related tissue breakdown was significantly reduced (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) post RAM. Multivariate logistic regression results showed the type of system (odds ratio [OR] 0.19, 95% CI 0.04\u20130.87;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .032) and total invasive ventilation time (OR 0.94, 95% CI 0.89\u20130.99;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) were predictors for the development of bronchopulmonary dysplasia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The ability to apply continuous distending pressure through consistent application of NRS with the RAM cannula attached to a ventilator may improve clinical outcomes, including the duration of respiratory support and pressure-ulcer rates. The influence of this system on the development of bronchopulmonary dysplasia and the significantly increased retinopathy of prematurity requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.05978","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T06:36:08Z","timestamp":1537425368000},"page":"1197-1206","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of Interfaces for the Delivery of Noninvasive Respiratory Support to Low Birthweight Infants"],"prefix":"10.1177","volume":"63","author":[{"given":"Gail S","family":"Drescher","sequence":"first","affiliation":[{"name":"Pulmonary Services Department, MedStar Washington Hospital Center, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy W","family":"Hughes","sequence":"additional","affiliation":[{"name":"Pulmonary Services Department, MedStar Washington Hospital Center, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2010.12.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.1.2107093"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20363"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09541252"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09541209"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.06.007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.304"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199609)22:3<188::AID-PPUL8>3.0.CO;2-L"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.75.3.F209"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.179416"},{"key":"e_1_3_3_12_2","unstructured":"Non-invasive mechanical ventilation and difficult weaning in critical care. 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