{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:32:09Z","timestamp":1788690729527,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>COPD is largely underdiagnosed. Patients with undiagnosed COPD need to be diagnosed to ensure early treatment institution. It is therefore relevant to obtain a more profound understanding of the characteristics of patients with undiagnosed COPD to improve COPD case finding. This study aimed to explore the characteristics of subjects with undiagnosed COPD from the United States National Health and Nutrition Examination Survey (NHANES) dataset (2007\u20132012) based on post-bronchodilator spirometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      A multitude of statistical tests were performed to explore the potential characteristics of subjects with undiagnosed COPD. A total of 1,098 subjects with a post-bronchodilator FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC &lt; 0.7 or lower limit of normal (LLN) were included in the final sample.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Undiagnosed subjects experienced less phlegm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), wheezing (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and chest pain (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) than subjects diagnosed with COPD. They were characterized by less shortness of breath (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), fewer work\/school days lost to wheezing (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), less sleep disturbance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and less difficulty socializing (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). The undiagnosed subjects felt less depressed (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Additionally, they were less likely to have asthma (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). The annual household income was higher among the undiagnosed subjects (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and they were also characterized by higher FEV\n                      <jats:sub>1<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and FVC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Subjects with undiagnosed COPD were characterized by fewer symptoms and had better lung function than their diagnosed counterparts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.06296","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T13:26:48Z","timestamp":1533648408000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Characteristics of Subjects With Undiagnosed COPD Based on Post-Bronchodilator Spirometry Data"],"prefix":"10.1177","volume":"64","author":[{"given":"Stine","family":"Hangaard","sequence":"first","affiliation":[{"name":"Department of Health Science and Technology, Medical Informatics Group, Aalborg University, Aalborg, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kronborg","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Medical Informatics Group, Aalborg University, Aalborg, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole K","family":"Hejlesen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Medical Informatics Group, Aalborg University, Aalborg, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"European Respiratory Society. 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