{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:35Z","timestamp":1790834495931,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Amyotrophic lateral sclerosis (ALS) is considered a multisystem degenerative disease due to its autonomic dysfunction effects. Autonomic cardiac control disorders can be seen in ALS and influence the quality of life and the life expectancy of affected individuals. We evaluated heart rate variability in subjects with ALS and with variable lung capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective cross-sectional study performed in 42 subjects with ALS. The subjects were classified into 2 groups according to their FVC: (FVC &gt; 50% of the predicted value [\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 19] and FVC &lt; 50% of the predicted value [\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 23]). Heart rate was recorded at rest during spontaneous breathing by using a heart rate monitor. Linear indices in the time and frequency domains were analyzed, and non-linear analysis was performed by using Poincar\u00e9 plots.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The results showed a decrease of heart rate variability in the subjects with lower lung capacity and who needed ventilatory support. Qualitative analysis when using the plots supported the quantitative analysis, wherein the group with a lower lung capacity showed reduced heart rate variability. No significant differences were found in the other heart rate variability indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The subjects with ALS and with decreased pulmonary capacity had reduced heart rate variability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.06681","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:25:24Z","timestamp":1559049924000},"page":"1088-1095","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Decreased Heart Rate Variability in Individuals With Amyotrophic Lateral Sclerosis"],"prefix":"10.1177","volume":"64","author":[{"given":"Renata M M","family":"Pimentel","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina da Universidade Federal de S\u00e3o Paulo, Departamento de Cardiologia, S\u00e3o Paulo, Brazil."},{"name":"Laborat\u00f3rio de Delineamento da Escrita Cient\u00edfica, Faculdade de Medicina do ABC, Santo Andr\u00e9, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Hugo","family":"Macedo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento da Escrita Cient\u00edfica, Faculdade de Medicina do ABC, Santo Andr\u00e9, S\u00e3o Paulo, Brazil."},{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade da Coletividade da Faculdade de Medicina do ABC, Departamento de Sa\u00fade Coletiva, Santo Andre, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edtor E","family":"Valenti","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Fisioterapia, UNESP, Presidente Prudente, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando O","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento da Escrita Cient\u00edfica, Faculdade de Medicina do ABC, Santo Andr\u00e9, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Abreu","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento da Escrita Cient\u00edfica, Faculdade de Medicina do ABC, Santo Andr\u00e9, S\u00e3o Paulo, Brazil."},{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade da Coletividade da Faculdade de Medicina do ABC, Departamento de Sa\u00fade Coletiva, Santo Andre, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Bandeira","family":"de M Monteiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento da Escrita Cient\u00edfica, Faculdade de Medicina do ABC, Santo Andr\u00e9, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina da Universidade Federal de S\u00e3o Paulo, Departamento de Cardiologia, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2015.10.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201608-1697ED"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-311945"},{"key":"e_1_3_3_5_2","volume-title":"Up-to-date","author":"Elman LB","year":"2012","unstructured":"Elman LB, , McCluskey L. 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