{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:59:31Z","timestamp":1783612771446,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Patients with intermediate-risk acute pulmonary embolism are at risk of hemodynamic deterioration, and identification of risk factors for decompensation could guide the administration of thrombolytics. We aimed to assess whether S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      on presentation is associated with early hemodynamic deterioration in this population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A retrospective chart review of subjects admitted between 2006 and 2018 with intermediate-risk pulmonary embolism (hemodynamically stable with right ventricle to left ventricle ratio &gt; 0.9 or tricuspid annular plane systolic excursion &lt; 18 mm). Early hemodynamic deterioration was defined as requirements for vasopressors or rescue thrombolytics within 48 h. Results are presented as median (interquartile range).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 178 subjects were included. Early hemodynamic deterioration occurred in 13% of the subjects and was associated with a median (interquartile range) lower S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      on presentation in univariate analysis (243 [123\u2013275] versus 438 [335\u2013457],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and in a multivariate analysis, including heart rate and right ventricle to left ventricle ratio as covariates (odds ratio 0.992, 95% CI 0.987\u20130.996;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). The initial S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      predicted hemodynamic deterioration with an area under the receiver operating characteristic curve of 0.81 and a threshold of 260 was associated with a sensitivity of 74% and specificity of 88%. Sensitivity analyses restricted to subjects with hypoxemia on presentation and subjects with an elevated troponin level led to similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      In intermediate-risk pulmonary embolism, S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      on presentation can help predict the risk of early hemodynamic deterioration.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.06797","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T18:15:21Z","timestamp":1557252921000},"page":"1279-1285","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["S\n                    <sub>\n                      pO\n                      <sub>2<\/sub>\n                    <\/sub>\n                    \/F\n                    <sub>\n                      IO\n                      <sub>2<\/sub>\n                    <\/sub>\n                    on Presentation as a Predictor for Early Hemodynamic Deterioration in Intermediate Risk Acute Pulmonary Embolism"],"prefix":"10.1177","volume":"64","author":[{"given":"Lisa","family":"Domaradzki","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Ghahramani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Rogers","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Ruzieh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andry","family":"Van de Louw","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu283"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07534-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137826.09715.9C"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-862OC"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-13-111"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00319-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00307-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03345.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204762"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.2.211"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.1.7599843"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.128.1.170"},{"issue":"2","key":"e_1_3_2_14_2","first-page":"332","article-title":"Determinants of hypoxemia during the acute phase of pulmonary embolism in humans","volume":"132","author":"Manier G","year":"1985","unstructured":"Manier G, , Castaing Y, , Guenard H. 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