{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:44:20Z","timestamp":1791420260570,"version":"4.3.3"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Use of negative pressure ventilation is neither well described nor widespread in pediatric critical care; existing data are from small, specialized populations. We sought to describe a general population of critically ill subjects with acute respiratory failure supported with negative pressure ventilation to find predictors of response or failure.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n We conducted a retrospective cohort study of subjects 0\u201318 y old admitted to a single (non-cardiac) pediatric ICU who received acute respiratory failure support via negative pressure ventilation from May 2015 through May 2016.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n In 118 subjects, the most common causes of acute respiratory failure were viral bronchiolitis (86.4%) and pneumonia (15.3%). A majority of subjects (68.6%) stabilized with negative pressure ventilation and did not need a change of respiratory support; in those who failed with negative pressure ventilation, median time to respiratory support change was 5.1 h (interquartile range 1.9\u201311.0). Subjects stabilized with negative pressure ventilation did not differ from those needing a change of respiratory support in terms of age, comorbidities, or F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n at initiation of ventilation. Compared to those who did not respond to negative pressure ventilation, mean S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n \/F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n was higher at 1 h after start of negative pressure ventilation (218.8 vs 131.7) in those who did respond. Subjects with S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n \/F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n < 192 after 1 h on negative pressure ventilation support had 5-fold higher odds of needing a respiratory support change (odds ratio 5.143, 95% CI 1.17\u201322.7,\n P<\/jats:italic>\n = .031). Analysis of S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n \/F\n \n IO\n 2<\/jats:sub>\n <\/jats:sub>\n was limited by 81.3% (96\/118) of subjects who had an S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n > 97% at 1 h after the start of negative pressure ventilation.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Negative pressure ventilation successfully supported 69% of pediatric subjects with all-cause acute respiratory failure. Oxygen requirement was lower in subjects who were responsive to negative pressure ventilation within 1 h of initiation. Standardized negative pressure ventilation protocols should include weaning of supplemental oxygen to determine responsiveness.<\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.07020","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T14:04:21Z","timestamp":1569938661000},"page":"91-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Predictors of Negative Pressure Ventilation Response in Pediatric Acute Respiratory Failure"],"prefix":"10.1177","volume":"65","author":[{"given":"Crystal A","family":"Nunez","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda B","family":"Hassinger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, John R Oishei Children's Hospital, Buffalo, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Principles and practice of mechanical ventilation","author":"Corrado A","year":"2013","unstructured":"Corrado A, , Gorini M. Negative pressure ventilation. In: Tobin MJ. editor. Principles and practice of mechanical ventilation, 3rd ed.. New York: McGraw-Hill; 2013.","edition":"3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1253"},{"key":"e_1_3_2_4_2","first-page":"43","article-title":"Continuous negative pressure in the treatment of infants with pulmonary hypertension and respiratory failure","volume":"9","author":"Sills JH","year":"1989","unstructured":"Sills JH, , Cvetnic WG, , Pietz J. Continuous negative pressure in the treatment of infants with pulmonary hypertension and respiratory failure. J Perinat, 1989; 9:43\u201348.","journal-title":"J Perinat"},{"issue":"11","key":"e_1_3_2_5_2","first-page":"CD003699","article-title":"Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children","author":"Shah PS","year":"2013","unstructured":"Shah PS, , Ohlsson A, , Shah JP. Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children. Cochrane Database Syst Rev, 2013;(11):CD003699.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05531"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305322"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4601-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2010.08.015"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1114-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23663"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21549"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.1.179"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.445"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.07020","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.07020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.07020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:26:31Z","timestamp":1775467591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.07020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.4187\/respcare.07020"],"URL":"https:\/\/doi.org\/10.4187\/respcare.07020","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}