{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:40:55Z","timestamp":1787913655483,"version":"build-2784847793"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2020,8]]},"abstract":"\n BACKGROUND:<\/jats:title>\n The objective of the current study was to determine whether overnight pulse oximetry in patients with amyotrophic lateral sclerosis is prognostic of the onset of awake respiratory failure and hospital admissions.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n This was an observational study in a cohort of subjects with amyotrophic lateral sclerosis. The study included subjects with a baseline\n \n \n \n \n S<\/mml:mtext>\n \n \n \n pO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n \u2265 94% on home overnight pulse oximetry testing. Patients age \u2265 80 y and those with comorbidities and with poor short-term prognosis or sleep apnea were excluded. The subjects were classified as nocturnal desaturators according to percentage of sleep time with\n \n \n \n \n S<\/mml:mtext>\n \n \n \n pO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n < 90% (T90) > 10%.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n A total of 76 subjects were included: 40 men (53%), mean \u00b1 SD age 60 \u00b1 14.4 y, mean \u00b1 SD body mass index 25.7 \u00b1 4.60 kg\/m\n 2<\/jats:sup>\n , and spinal presentation in 63.2%. After overnight pulse oximetry, 20 subjects (26%) were classified as desaturators and 56 (74%) as non-desaturators. In the first year, the subjects with nocturnal desaturation had respiratory failure more often compared with the subjects without desaturation (35% vs 10.91%;\n P<\/jats:italic>\n = .02) and had a higher risk of developing respiratory failure during the course of the study (hazard ratio 2.48;\n P<\/jats:italic>\n = .030). The desaturator group also had a higher rate of \u2265 1 admission (40% vs 7.3%;\n P<\/jats:italic>\n = .01) and a higher likelihood of respiratory-related hospitalization (hazard ratio 2.41;\n P<\/jats:italic>\n = .02). Median survival was almost 1 year less if T90 > 10% was observed in the overnight pulse oximetry: 21 months versus 32 months survival if T90 was \u2264 10%.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In subjects with amyotrophic lateral sclerosis, nocturnal desaturation conferred a higher risk of respiratory failure and poorer prognosis. Even in the absence of other clinical criteria, early pulse oximetry should be performed and the need for nocturnal ventilatory support assessed.<\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.07154","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T15:45:10Z","timestamp":1584459910000},"page":"1128-1134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Overnight Pulse Oximetry to Determine Prognostic Factors in Subjects With Amyotrophic Lateral Sclerosis"],"prefix":"10.1177","volume":"65","author":[{"given":"Silvia Mart\u00edn","family":"Bote","sequence":"first","affiliation":[{"name":"UGC Neumolog\u00eda, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Pascual","family":"Martinez","sequence":"additional","affiliation":[{"name":"UGC Neumolog\u00eda, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Esteban","family":"Amarilla","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Piti\u00e9-Sal\u00eatri\u00e8re. Service de Pneumologie et R\u00e9animation Medicale du D\u00e9partement R3S, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar Font","family":"Ugalde","sequence":"additional","affiliation":[{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, C\u00f3rdoba, Spain."},{"name":"Medicine Department, University of C\u00f3rdoba, C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Gonzalez-Bermejo","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, UMRS 1158, Neurophysiologie Respiratorire Exp\u00e9rimentale et Clinique, Paris, France."},{"name":"AP-HP, Groupe Hospitalier Piti\u00e9-Sal\u00eatriere Charles Foix, Service de Pneumologie et R\u00e9animation Medicale du D\u00e9partement R3S, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria Feu","family":"Collado","sequence":"additional","affiliation":[{"name":"UGC Neumolog\u00eda, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernabe Jurado","family":"Gamez","sequence":"additional","affiliation":[{"name":"UGC Neumolog\u00eda, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, C\u00f3rdoba, Spain."},{"name":"Medicine Department, University of C\u00f3rdoba, C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343008.26874.d1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000048208.54755.78"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600863951"},{"issue":"1","key":"e_1_3_2_5_2","first-page":"33","article-title":"Respiratory function in amyotrophic lateral sclerosis patients. 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