{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:19:49Z","timestamp":1775474389936,"version":"3.50.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Patient-ventilator synchrony in patients with COPD is at risk during noninvasive ventilation (NIV). NIV in neurally-adjusted ventilatory assist (NAVA) mode improves synchrony compared to pressure support ventilation (PSV). The current study investigated patient-ventilator interaction at 2 levels of NAVA and PSV mode in subjects with COPD exacerbation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      NIV was randomly applied at 2 levels (5 and 15 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O) of PSV and NAVA. Patient-ventilator interaction was evaluated by comparing airway pressure and electrical activity of the diaphragm waveforms with automated computer algorithms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      8 subjects were included. Trigger delay was longer in PSV high (268 \u00b1 112 ms) than in PSV low (161 \u00b1 118 ms,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .043), and trigger delay during NAVA was shorter than PSV for both low support (49 \u00b1 24 ms for NAVA,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .035) and high support (79 \u00b1 276 ms for NAVA,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .003). No difference in cycling error for low and high levels of PSV (PSV low \u2212100 \u00b1 114 ms and PSV high 56 \u00b1 315 ms) or NAVA (NAVA low \u22125 \u00b1 18 ms, NAVA high 12 \u00b1 36 ms) and no difference between PSV and NAVA was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Increasing PSV levels during NIV caused a progressive mismatch between neural effort and pneumatic timing. Patient-ventilator interaction during NAVA was more synchronous than during PSV, independent of inspiratory support level. (ClinicalTrials.gov registration NCT01791335.)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.07159","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T15:19:22Z","timestamp":1583853562000},"page":"1315-1322","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Patient-Ventilator Interaction During Noninvasive Ventilation in Subjects With Exacerbation of COPD: Effect of Support Level and Ventilator Mode"],"prefix":"10.1177","volume":"65","author":[{"given":"Eline","family":"Oppersma","sequence":"first","affiliation":[{"name":"Cardiovascular and Respiratory Physiology, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands."},{"name":"Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, Enschede, The Netherlands."},{"name":"Department of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonne","family":"Doorduin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands."},{"name":"Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisanne H","family":"Roesthuis","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes G","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H","family":"Veltink","sequence":"additional","affiliation":[{"name":"Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, Enschede, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo MA","family":"Heunks","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands."},{"name":"Department of Intensive Care Medicine, Amsterdam UMC, Amsterdam, The 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