{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:07:08Z","timestamp":1788217628067,"version":"build-2803163510"},"reference-count":51,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Various studies have been performed to examine the effect of high-flow nasal cannula (HFNC) in immunocompromised patients with acute respiratory failure (ARF). However, the results were inconsistent. Thus, we conducted a meta-analysis to evaluate the effect of HFNC oxygen therapy in immunocompromised patients with ARF versus conventional oxygen therapy and noninvasive ventilation (NIV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Relevant studies published prior to May 11, 2019, were systematically searched. The primary outcome was intubation rate; secondary outcomes were mortality (ICU mortality, in-hospital mortality, and 90-d mortality) and ICU-acquired infections. Data were pooled using the random effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of 832 identified studies, 8 were eligible for inclusion in our analysis (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 2,167 subjects). HFNC was associated with lower intubation rates compared to conventional oxygen therapy (risk ratio [RR] 0.89, 95% CI 0.79\u20131.00,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .040), but we found no significant difference in the rate between HFNC and NIV (RR 0.74, 95% CI 0.46\u20131.19,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .22). We also found that HFNC did not increase the risk of ICU-acquired infections (RR 0.86, 95% CI 0.63\u20131.18,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .35). However, in comparison to other noninvasive therapies, HFNC exhibited no differences in ICU mortality (RR 0.82, 95% CI 0.58\u20131.17,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .28), in-hospital mortality (RR 0.92, 95% CI 0.74\u20131.15,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .48), or 90-d mortality (RR 0.98, 95% CI 0.81\u20131.18,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our results suggest that HFNC may be a feasible alternative to NIV, with lower intubation rates and no increased risk for ICU-acquired infections compared to standard oxygen therapy. However, HFNC did not appear to reduce mortality in immunocompromised subjects with ARF compared with other noninvasive therapies. Further high-quality randomized controlled trials should be performed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.07205","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T17:15:33Z","timestamp":1574183733000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of High-Flow Nasal Cannula Oxygen Therapy in Immunocompromised Subjects With Acute Respiratory Failure"],"prefix":"10.1177","volume":"65","author":[{"given":"Hanyujie","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department 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