{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:54:50Z","timestamp":1775469290667,"version":"3.50.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2020,8]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n Extended periods of hypocarbia in preterm infants may be associated with intraventricular hemorrhage, periventricular leukomalacia, and bronchopulmonary dysplasia. To evaluate the current anesthetic practice in preterm neonates, we retrospectively reviewed the intraoperative course with regard to\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n and ventilation during non-cardiac surgical procedures in infants <60 weeks postmenstrual age.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n This was a single-center, retrospective study during non-cardiac surgical procedures in neonates. Hyperventilation was defined as a\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n \u2264 35 mm Hg, significant hyperventilation as a\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n \u2264 30 mm Hg, and extreme hyperventilation as a\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n \u2264 25 mm Hg.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n The study cohort included 112 neonates, with a median postnatal age of 40 weeks, median gestational age of 38 weeks, and median weight of 5 kg. Thirty-seven subjects (33%) had at least one arterial blood gas value that demonstrated hyperventilation. Thirteen (12%) were noted to have significant hyperventilation (\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n \u2264 30 mm Hg) and 2 had extreme hyperventilation (\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n \u2264 25 mm Hg).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n The incidence of at least one arterial blood gas that demonstrated inadvertent hyperventilation in neonates was high during intraoperative care. These data may provide the baseline for future studies that address more rigorous monitoring and control of\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n during intraoperative care. Although the duration of the anesthetic care and surgical procedure is brief compared with the neonatal ICU length of stay because there is no demonstrated benefit of hypocapnia and, in fact, well-documented harm associated with hyperventilation in neonates, care should be directed at limiting inadvertent hyperventilation. (ClinicalTrials.gov registration NCT03823716.)\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.07382","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T15:45:11Z","timestamp":1584459911000},"page":"1154-1159","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Incidence and Severity of Hypocarbia in Neonates Undergoing General Anesthesia"],"prefix":"10.1177","volume":"65","author":[{"given":"Kristin","family":"Chenault","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Nationwide Children\u2019s Hospital, Columbus, Ohio."},{"name":"Department of Anesthesiology and Pain Medicine, The Ohio State University College of Medicine, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Wakimoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Nationwide Children\u2019s Hospital, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Nationwide Children\u2019s Hospital, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Nationwide Children\u2019s Hospital, Columbus, Ohio."},{"name":"Department of Anesthesiology and Pain Medicine, The Ohio State University College of Medicine, Columbus, Ohio."},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12310"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1944451612449182"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8926"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00041.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2434"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-017-2446-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-008-0035-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12107.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14113"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000472"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31816a68c6"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.02930.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302649"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05801"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326080"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304613"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00204-0"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.07382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.07382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.07382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:56:11Z","timestamp":1775465771000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.07382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,17]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.4187\/respcare.07382"],"URL":"https:\/\/doi.org\/10.4187\/respcare.07382","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,17]]}}}