{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:55:21Z","timestamp":1775469321046,"version":"3.50.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The use of high-frequency oscillatory ventilation (HFOV) is backed by sound physiologic rationale, but clinical data on the elective use of HFOV have been largely disappointing. Nonetheless, HFOV is still occasionally used as a rescue mode in patients with severe hypoxemia. The evidence that supports this practice is sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This was a retrospective single-center analysis that involved subjects admitted to the medical ICU at Cleveland Clinic, Cleveland, Ohio. We included all adult patients (ages &gt; 18 y) who received rescue HFOV between January 1, 2010, and December 31, 2018, and analyzed their clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 48 subjects were included in the analysis. The most common primary diagnosis was pneumonia (\n                      <jats:italic toggle=\"yes\">n =<\/jats:italic>\n                      33 [68.8%]), followed by aspiration (\n                      <jats:italic toggle=\"yes\">n =<\/jats:italic>\n                      6 [12.5%]) and diffuse alveolar hemorrhage (\n                      <jats:italic toggle=\"yes\">n =<\/jats:italic>\n                      2 [4.2%]). Switching to HFOV improved oxygenation but also increased vasopressor requirements at 3 h. The mortality rate of the study population was 92% (44\/48).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our study did not support utilization of HFOV as a \u201clast-ditch\u201d rescue measure in subjects with respiratory failure. The delayed timing of HFOV initiation and its detrimental hemodynamic effects are among the potential reasons for the high mortality rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.08936","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T15:00:12Z","timestamp":1629817212000},"page":"1746-1751","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of High-Frequency Oscillatory Ventilation as a Rescue Strategy in Respiratory Failure"],"prefix":"10.1177","volume":"66","author":[{"given":"Guramrinder Singh","family":"Thind","sequence":"first","affiliation":[{"name":"Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umur","family":"Hatipo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L","family":"Chatburn","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Duggal","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Mireles-Cabodevila","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2016-0012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199706000-00004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215716"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215554"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201704-341OT"},{"issue":"2","key":"e_1_3_2_7_2","first-page":"175","article-title":"High-frequency oscillatory ventilation: still a role?","volume":"23","author":"Ng J","year":"2017","unstructured":"Ng J, , Ferguson ND. High-frequency oscillatory ventilation: still a role?. Curr Opin Crit Care, 2017; 23(2):175-179.","journal-title":"Curr Opin Crit Care"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01355"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.29390\/cjrt-2019-004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04584"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1938OC"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.6.1619"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704154"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03057"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800385"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001888-200410001-00022"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0843-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182451b4a"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.08936","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.08936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.08936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:56:17Z","timestamp":1775465777000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.08936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.4187\/respcare.08936"],"URL":"https:\/\/doi.org\/10.4187\/respcare.08936","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,24]]}}}