{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:56:01Z","timestamp":1775469361043,"version":"3.50.1"},"reference-count":16,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2021,11]]},"abstract":"\n BACKGROUND:<\/jats:title>\n High-frequency jet ventilation (HFJV) is primarily used in neonates but may also have a role in the treatment of infants with congenital heart disease and severe respiratory failure. We hypothesized that HFJV would result in improved gas exchange in these infants.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n We retrospectively reviewed the records of all pediatric patients with complex congenital heart disease treated HFJV in our pediatric cardiac ICU between 2014 and 2018. Patients in whom HFJV was started while on extracorporeal membrane oxygenation (ECMO) were excluded. We extracted data on demographics, pulmonary mechanics, gas exchange, the subsequent need for ECMO, use of inhaled nitric oxide, and outcomes.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n We included 27 subjects (median [interquartile range {IQR}] weight 4.4 [3.3\u20135.4] kg; median [IQR] age 2.5 [0.3\u20135.4] months), 22 (82%) of whom had cyanotic heart disease. Thirteen subjects (48%) survived and 6 (22%) required ECMO. HFJV was started after a median (IQR) of 8.4 (2.1\u201326.3) d of conventional mechanical ventilation. The subjects spent a median (IQR) of 1.2 (0.5\u20132.8) d on HFJV. The median (IQR) pre-HFJV blood gas results (\n n =<\/jats:italic>\n 25) were pH 7.22 (7.17\u20137.31),\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 69 (51\u201377) mm Hg, and\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 51 (41\u201376) mm Hg. Median (IQR) initial HFJV settings were peak inspiratory pressure of 45 (36\u201350) cm H\n 2<\/jats:sub>\n O, breathing frequency of 360 (360\u2013380) breaths\/min, and inspiratory time of 0.02 (0.02\u20130.03) s. Compared with conventional mechanical ventilation, at 4\u20136 h after HFJV initiation, there were significant improvements in the median pH (7.22 vs 7.34;\n P<\/jats:italic>\n = .001) and\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n (69 vs 50 mm Hg;\n P<\/jats:italic>\n = .001), respectively, but no difference in median\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n (51 vs 53 mm Hg;\n P<\/jats:italic>\n = .97).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n HFJV was associated with a decrease in\n \n \n \n \n P<\/mml:mtext>\n \n \n \n aCO<\/mml:mtext>\n <\/mml:mrow>\n 2<\/mml:mtext>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n and an increase in pH in infants with congenital heart disease who remained on HFJV 4 to 6 h after initiation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.09186","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T11:35:59Z","timestamp":1623238559000},"page":"1684-1690","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["High-Frequency Jet Ventilation in Infants With Congenital Heart Disease"],"prefix":"10.1177","volume":"66","author":[{"given":"Andrew G","family":"Miller","sequence":"first","affiliation":[{"name":"Respiratory Care Services, Duke University Medical Center, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briana L","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Duke Children\u2019s Hospital, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M","family":"Gates","sequence":"additional","affiliation":[{"name":"Respiratory Care Services, Duke University Medical Center, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn E","family":"Haynes","sequence":"additional","affiliation":[{"name":"Respiratory Care Services, Duke University Medical Center, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise A","family":"Lopez Domowicz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Duke Children\u2019s Hospital, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre T","family":"Rotta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Duke Children\u2019s Hospital, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-9813(00)00051-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2015.10.017"},{"issue":"0","key":"e_1_3_2_4_2","first-page":"0","article-title":"A narrative review of advanced ventilator modes in the pediatric intensive care unit","volume":"0","author":"Miller AG","unstructured":"Miller AG, , Bartle RM, , Feldman A, , Mallory P, , Reyes E, , Scott B, et al. A narrative review of advanced ventilator modes in the pediatric intensive care unit. Transl Pediatr, in press; 0(0):0-0.","journal-title":"Transl Pediatr"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08691"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08241"},{"issue":"4","key":"e_1_3_2_7_2","first-page":"92","article-title":"High frequency jet ventilation in respiratory failure secondary to respiratory syncytial virus infection: a case series","author":"Valentine KM","year":"2016","unstructured":"Valentine KM, , Sarnaik AA, , Sandhu HS, , Sarnaik AP. High frequency jet ventilation in respiratory failure secondary to respiratory syncytial virus infection: a case series. Front Pediatr, 2016;(4):92.","journal-title":"Front Pediatr"},{"issue":"5","key":"e_1_3_2_8_2","first-page":"II127","article-title":"High-frequency jet ventilation for respiratory failure after congenital heart surgery","volume":"86","author":"Kocis KC","year":"1992","unstructured":"Kocis KC, , Meliones JN, , Dekeon MK, , Callow LB, , Lupinetti FM, , Bove EL. High-frequency jet ventilation for respiratory failure after congenital heart surgery. Circulation, 1992; 86(5 Suppl):II127-II132.","journal-title":"Circulation"},{"issue":"5","key":"e_1_3_2_9_2","first-page":"III364","article-title":"High-frequency jet ventilation improves cardiac function after the Fontan procedure","volume":"84","author":"Meliones JN","year":"1991","unstructured":"Meliones JN, , Bove EL, , Dekeon MK, , Custer JR, , Moler FW, , Callow LR, et al. High-frequency jet ventilation improves cardiac function after the Fontan procedure. Circulation, 1991; 84(5 Suppl):III364-III368.","journal-title":"Circulation"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.73.4.426"},{"issue":"5","key":"e_1_3_2_11_2","first-page":"332","article-title":"Ventilatory and hemodynamic effects of high-frequency jet ventilation following cardiac surgery","volume":"32","author":"Weiner JH","year":"1987","unstructured":"Weiner JH, , Chatburn RL, , Wa C. Ventilatory and hemodynamic effects of high-frequency jet ventilation following cardiac surgery. 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