{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:42:40Z","timestamp":1790923360648,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>One of the most common causes of respiratory distress in newborns is transient tachypnea of the newborn (TTN). Salbutamol is often suggested to increase the rate of pulmonary fluid absorption in newborns with TTN. This study aimed to evaluate the efficacy of inhaled salbutamol in TTN management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      This double-blind clinical trial was conducted on 52 newborns admitted to the neonatal ICU of Fatemieh Hospital of Hamadan, Iran. The newborns were randomly assigned to 2 groups of equal members: one group received 2 mL of nebulized sodium chloride concentration (control group), and the other group was treated with 0.1 mg\/kg of salbutamol (treatment group). The clinical outcomes were then compared before and 0.5, 1, and 4 h after the intervention. The data were recorded in a checklist and then were statistically analyzed in SPSS 16: the significant level was decided to be\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The comparison of TTN scores revealed a significant difference between the 2 groups 1 h (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005) and 4 h (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001 per\n                      <jats:xref ref-type=\"table\">Table 3<\/jats:xref>\n                      ) after the intervention. Moreover, the mean F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      1 h after the intervention was 53.3 \u00b1 6.6 in the treatment group and 57.7 \u00b1 7.5 in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). The mean duration of respiratory support in the treatment and control groups was 2.4 \u00b1 2.7 and 3.1 \u00b1 0.8 d, respectively, (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002). The findings suggested no statistically significant difference between the 2 groups regarding the adverse effects, length of stay (LOS), duration of antibiotics intake, oral feeding resumption time, and maximum oral feeding time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; .05 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The study results indicated that inhaled salbutamol significantly decreased the TTN clinical score, oxygen demands, and duration of respiratory support, whereas there was no significant difference between the groups in terms of LOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09284","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T15:45:17Z","timestamp":1636472717000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Inhaled Salbutamol on Transient Tachypnea of the Newborn"],"prefix":"10.1177","volume":"67","author":[{"given":"Behnaz","family":"Basiri","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishteman","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kazem","family":"Sabzehei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh Esna","family":"Ashari","sequence":"additional","affiliation":[{"name":"Hamadan Medical School, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"96","volume-title":"Respiratory Care: Principles and Practice","author":"MacIntyre NR","year":"2015","unstructured":"MacIntyre NR, , Galvin WF, , Mishoe SC. 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