{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:47:31Z","timestamp":1784126851234,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Children with asthma exacerbations requiring pediatric ICU (PICU) admission, known as critical asthma (CA), are prescribed a variety of therapeutic interventions including heliox. Delivered invasively and noninvasively, heliox is employed to enhance deposition of aerosolized medications, improve obstructive pulmonary pathophysiology, and avoid complications associated with invasive mechanical ventilation. We used the Virtual Pediatric Systems database to update estimates of heliox prescription and explore for relationships between heliox and mechanical ventilation frequency and duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study using data from 97 PICUs among children 3\u201317 y of age admitted for CA from 2013\u20132019. The primary outcome was heliox prescribing rates and trends. Subgroup analyses assessed mechanical ventilation rates and duration by heliox exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of 43,238 subjects studied, 1,070 (2.5%) were prescribed heliox. Mean heliox prescribing rates fell from 4.11% in 2013 to 2.37% in 2019. Heliox use was greater from centers in the South (2.6%) and Midwest (3.3%) as compared to the West (1.6%) and Northeast United States (1.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). In the subgroup assessing mechanical ventilation frequency, mechanical ventilation rates were 273\/39,739 (0.7%) and greater for those provided heliox (1.9% vs 0.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). In the subgroup assessing mechanical ventilation duration, no differences in median mechanical ventilation duration were observed (4.94 [interquartile range [IQR] 3.04\u20136.36] vs 4.63 [IQR 3.11\u20137.30] d;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .35) for those with and without heliox. In exploratory adjusted models, noninvasive heliox was not associated with mechanical ventilation. Mortality was rare (206\/43,238 [0.47%]) and predominantly among subjects intubated prehospitalization (188\/206 [91.3%]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Heliox as adjunctive therapy for children with CA is uncommon (2.5%) and not associated with mechanical ventilation or decreased mechanical ventilation duration in adjusted models. Updated estimates provided herein inform prospective controlled trial development to better define the role of heliox for CA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09385","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T07:33:50Z","timestamp":1678433630000},"page":"510-519","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Heliox Prescribing Trends for Pediatric Critical Asthma"],"prefix":"10.1177","volume":"67","author":[{"given":"Alicia","family":"Lew","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of South Florida College of Medicine, Tampa, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins All Children\u2019s Hospital, St. Petersburg, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"K Amankwah","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins All Children\u2019s Hospital, St. Petersburg, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A","family":"Sochet","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care Medicine, Johns Hopkins All Children\u2019s Hospital, St. Petersburg, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3318"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2233C"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-016-0029-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24554"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.02.041"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617740079"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1733"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318238b428"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05174"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2009.10.008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-019-04116-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0763PP"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000154946.62733.94"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.09.024"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.07520582"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04491038"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000070584.00490.7B"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.2.2006105"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.2.296"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.5.1256"},{"key":"e_1_3_3_22_2","first-page":"088506662110265","article-title":"Heliox for pediatric critical asthma: a multi-center, retrospective, registry-based descriptive study","author":"Lew A","year":"2021","unstructured":"Lew A, , Morrison JM, , Amankwah E, , Sochet AA. Heliox for pediatric critical asthma: a multi-center, retrospective, registry-based descriptive study. J Intensive Care Med, 2021:088506662110265.","journal-title":"J Intensive Care Med"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70346-9"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2136"},{"issue":"3","key":"e_1_3_3_25_2","first-page":"356","article-title":"Helium\/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: a randomized, placebo-controlled trial","volume":"11","author":"Bigham MT","year":"2010","unstructured":"Bigham MT, , Jacobs BR, , Monaco MA, , Brilli RJ, , Wells D, , Conway EM, et al. Helium\/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: a randomized, placebo-controlled trial. Pediatr Crit Care Med, 2010; 11(3):356-361.","journal-title":"Pediatr Crit Care Med"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.06.007"},{"issue":"4","key":"e_1_3_3_27_2","first-page":"CD002884","article-title":"Heliox for non-intubated acute asthma patients","author":"Rodrigo G","year":"2003","unstructured":"Rodrigo G, , Pollack C, , Rodrigo C, , Rowe BH. Heliox for non-intubated acute asthma patients. 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