{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:27:53Z","timestamp":1785457673092,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>During the coronavirus disease 2019 (COVID-19) pandemic, 60\u201380% of patients admitted to ICU require mechanical ventilation for respiratory distress. We aimed to compare the frequency of postextubation stridor (PES) and to explore risk factors in COVID-19 subjects compared to those without COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We performed an observational retrospective study on subjects admitted for severe COVID-19 requiring mechanical ventilation &gt; 48 h during the first and second waves in 2020 and compared these subjects to historical controls without COVID-19 who received mechanical ventilation &gt; 48 h between 2016\u20132019. The primary outcome was the frequency of PES, defined as audible stridor within 2 h following extubation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the 134 subjects admitted with severe COVID-19 requiring mechanical ventilation, 96 were extubated and included and compared to 211 controls. The frequency of PES was 22.9% in the COVID-19 subjects and 3.8% in the controls\n                      <jats:italic toggle=\"yes\">(P<\/jats:italic>\n                      &lt; .001). Factors independently associated with PES were having COVID-19 (odds ratio 3.72, [95% CI 1.24\u201312.14],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02), female sex (odds ratio 5.77 [95% CI 2.30\u201315.64],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and tube mobilization or re-intubation or prone positioning (odds ratio 3.01 [95% CI 1.04\u20139.44],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .047) after adjustment on Simplified Acute Physiology Score II expanded). During the first wave, PES was significantly more common in subjects with a positive SARS-CoV-2 RT-PCR test on tracheal samples on the day of extubation (73.3% vs 24.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>PES affected nearly one-quarter of subjects with COVID-19, a proportion significantly higher than that seen in controls. Independent risk factors for PES were COVID-19, female sex, and tube mobilization or re-intubation or prone positioning. PES was associated with persistent viral shedding at the time of extubation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09527","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T11:05:11Z","timestamp":1647947111000},"page":"638-646","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Postextubation Stridor in Severe COVID-19"],"prefix":"10.1177","volume":"67","author":[{"given":"Georges Abi","family":"Abdallah","sequence":"first","affiliation":[{"name":"Medical-Surgical Intensive Care Department Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Medical-Surgical Intensive Care Department Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gros","sequence":"additional","affiliation":[{"name":"Medical-Surgical Intensive Care Department Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Simon","sequence":"additional","affiliation":[{"name":"Anaesthesia Department Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bruneel","sequence":"additional","affiliation":[{"name":"Medical-Surgical Intensive Care Department Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Marque-Juillet","sequence":"additional","affiliation":[{"name":"Microbiology Department, Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Legriel","sequence":"additional","affiliation":[{"name":"Medical-Surgical Intensive Care Department Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France; and University Paris-Saclay, UVSQ, INSERM, CESP, PsyDev Team, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Paul","sequence":"additional","affiliation":[{"name":"Medical-Surgical Intensive Care Department Centre Hospitalier de Versailles - Site Andre Mignot, Le Chesnay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1018-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172096"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3031"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.042"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202008-3265OC"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-021-00825-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30316-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004457"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03244-3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa851"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15092"},{"issue":"9","key":"e_1_3_3_14_2","first-page":"e10492","article-title":"Postextubation stridor complicating COVID-19\u2013associated acute respiratory distress syndrome: a case series","volume":"12","author":"Moran JV","year":"2020","unstructured":"Moran JV, , Godil SA, , Goldner B, , Godil K, , Aslam J. 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