{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:17:13Z","timestamp":1788250633239,"version":"build-2803163510"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The impact of mechanical ventilation parameters and management on outcomes of patients with coronavirus disease 2019 (COVID-19) ARDS is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This multi-center observational study enrolled consecutive mechanically ventilated patients with COVID-19 ARDS admitted to one of 7 Korean ICUs between February 1, 2020\u2013February 28, 2021. Patients who were age &lt; 17 y or had missing ventilation parameters for the first 4 d of mechanical ventilation were excluded. Multivariate logistic regression was used to identify which strategies or ventilation parameters that were independently associated with ICU mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Overall, 129 subjects (males, 60%) with a median (interquartile range) age of 69 (62\u201378) y were included. Neuromuscular blocker (NMB) use and prone positioning were applied to 76% and 16% of subjects, respectively. The ICU mortality rate was 37%. In the multivariate analysis, higher dynamic driving pressure (\u0394P) values during the first 4 d of mechanical ventilation were associated with increased mortality (adjusted odds ratio 1.16 [95% CI 1.00\u20131.33]\n                      <jats:italic toggle=\"yes\">, P<\/jats:italic>\n                      = .046). NMB use was associated with decreased mortality (adjusted odds ratio 0.27 [95% CI 0.09\u20130.81],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). The median tidal volume values during the first 4 d of mechanical ventilation and the ICU mortality rate were significantly lower in the NMB group than in the no NMB group. However, subjects who received NMB for \u2265 6 d (vs &lt; 6 d) had higher ICU mortality rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In subjects with COVID-19 ARDS receiving mechanical ventilation, \u0394P during the first 4 d of mechanical ventilation was independently associated with mortality. The short-term use of NMB facilitated lung-protective ventilation and was independently associated with decreased mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09577","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T14:08:02Z","timestamp":1638281282000},"page":"216-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Lower Driving Pressure and Neuromuscular Blocker Use Are Associated With Decreased Mortality in Patients With COVID-19 ARDS"],"prefix":"10.1177","volume":"67","author":[{"given":"Bo Young","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Allergy and Respiratory Diseases, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-I","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Seong","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae-Rin","family":"Baek","sequence":"additional","affiliation":[{"name":"Division of Allergy and Pulmonology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Sub","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Critical Care Medicine, Chosun University Hospital, Gwangju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil Myeong","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208707"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.200794"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06256-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0817LE"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06281-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03536-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901686"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004363"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"},{"issue":"23","key":"e_1_3_2_15_2","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"ARDS Definition Task Force;","year":"2012","unstructured":"ARDS Definition Task Force;. Ranieri VM, , Rubenfeld GD, , Thompson BT, , Ferguson ND, , Caldwell E, , Fan E, et al. Acute respiratory distress syndrome: the Berlin definition. 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