{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:31:35Z","timestamp":1787031095368,"version":"build-2736575974"},"reference-count":48,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Home noninvasive ventilation (NIV) is increasingly used in amyotrophic lateral sclerosis (ALS) to improve symptoms and survival. Our primary objective was to compare intelligent volume-assured pressure support (iVAPS) versus spontaneous\/timed (S\/T) modes regarding time to first change in ventilator parameters and the number of interventions over 6 months in subjects with ALS in a respiratory therapist (RT)-led program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>In this study, 30 subjects with ALS meeting criteria for NIV initiation were randomized to iVAPS or S\/T. NIV was initiated using standardized protocols targeting optimal tidal volume and comfort in a daytime session. Download data were recorded at 1 week and 1 and 6 months. Any changes in ventilator parameters were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the 30 subjects, 56.7% had bulbar onset ALS, 8 died, and 11 in each group completed the study. Median time to first parameter change was 33.5 (interquartile range [IQR] 7.7\u201396.0) d versus 41.0 (IQR 12.5\u2013216.5) d for iVAPS versus S\/T groups, respectively,\n                      <jats:italic toggle=\"yes\">(P<\/jats:italic>\n                      \u2009=\u2009.48). The average number of RT interventions was similar between groups (1.1\u2009\u00b1\u20091.1 vs 0.9\u2009\u00b1\u20090.9 at 1 month,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.72; 2.4\u2009\u00b1\u20092.1 vs 2.4\u2009\u00b1\u20092.3 at 6 months,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.95, for iVAPS vs S\/T, respectively). Adherence was significantly lower with iVAPS than S\/T at 1 week but not at 1 or 6 months. Download parameters were similar between groups at 1 week and 6 months except for higher residual apnea-hypopnea index (AHI) and less spontaneously triggered breaths with iVAPS at 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The time to first change of parameters and the number of interventions at 6 months from NIV initiation were similar for the iVAPS and S\/T modes in subjects with ALS. With iVAPS, adherence was lower transiently at NIV initiation, and the residual AHI was higher at 6 months. Alveolar ventilation-targeted NIV may require a longer adaptation period and result in greater upper-airway instability predominantly in patients with bulbar ALS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09580","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T09:40:15Z","timestamp":1653990015000},"page":"1109-1120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Alveolar Ventilation-Targeted Versus Spontaneous\/Timed Mode for Home Noninvasive Ventilation in Amyotrophic Lateral Sclerosis"],"prefix":"10.1177","volume":"67","author":[{"given":"Pattaraporn","family":"Panyarath","sequence":"first","affiliation":[{"name":"Respiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, Quebec, Canada; and Division of Respiratory and Respiratory Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Adam","sequence":"additional","affiliation":[{"name":"Quebec National Program for Home Ventilatory Assistance, McGill University Health Centre, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R John","family":"Kimoff","sequence":"additional","affiliation":[{"name":"Respiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, Quebec, Canada; and Center for Research Outcomes Evaluation, McGill University Health Centre, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Kaminska","sequence":"additional","affiliation":[{"name":"Respiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, Quebec, Canada; Center for Research Outcomes Evaluation, McGill University Health Centre, Montreal, Quebec, Canada; and Quebec National Program for Home Ventilatory Assistance, McGill University Health Centre, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.409"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09652-y"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70244-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.5.1155"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003\/erj.9.7.1515"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-6-199709150-00006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00052-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.855790"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00578"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70326-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000076182.13137.38"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.1.153"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00617-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000227785.73714.64"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.881376"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2016.1165256"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310055"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202002-169OC"},{"issue":"10","key":"e_1_3_3_20_2","first-page":"CD004427","article-title":"Mechanical ventilation for amyotrophic lateral sclerosis\/motor neuron disease","volume":"10","author":"Radunovic A","year":"2017","unstructured":"Radunovic A, , Annane D, , Rafiq MK, , Brassington R, , Mustfa N. 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