{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:35:36Z","timestamp":1775471736988,"version":"3.50.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Patients with ARDS due to COVID-19 may require tracheostomy and transfer to a weaning center. To date, data on the outcome of these patients are scarce. The objectives of this study were to determine the factors associated with time to decannulation and limb-muscle strength recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This was an observational retrospective study of subjects with COVID-19\u2013related ARDS requiring tracheostomy after prolonged ventilation, who were subsequently transferred to a weaning center from April 4, 2020\u2013May 30, 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Forty-three subjects were included. Median age (interquartile range) was 61 (48\u201366) y; 81% were men, and median body mass index (BMI) was 30 (26\u201335) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Tracheostomy was performed after a median of 19 (12\u201327) d of mechanical ventilation, and the median ICU length of stay prior to transfer to the weaning center was 30 (21\u201346) d. On admission to the weaning center, the median Medical Research Council (MRC) score was 36 (27\u201344). Time to decannulation was 9 (7\u201318) d after admission to the weaning center. The only factor independently associated with early decannulation was the MRC score on admission to the weaning center (odds ratio 1.16 [95% CI 1.06\u20131.31],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005). Two factors were independently associated with MRC gain \u2265 10: BMI (odds ratio 0.88 [95% CI 0.76\u20130.99],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .045) and MRC on admission (odds ratio 0.91 [95% CI 0.82\u20130.98],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03. Three months after admission to the weaning center, 40 subjects (93%) were weaned from mechanical ventilation and 36 (84%) had returned home.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>MRC score at weaning center admission predicted both early decannulation and limb-muscle strength recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09602","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T09:40:18Z","timestamp":1653990018000},"page":"967-975","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Specialized Weaning Unit in the Trajectory of SARS-CoV-2 ARDS: Influence of Limb Muscle Strength on Decannulation and Rehabilitation"],"prefix":"10.1177","volume":"67","author":[{"given":"Morgane","family":"Faure","sequence":"first","affiliation":[{"name":"APHP-6 Sorbonne Universit\u00e9, site Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Intensive - R\u00e9animation (D\u00e9partement R3S), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxens","family":"Decav\u00e8le","sequence":"additional","affiliation":[{"name":"APHP-6 Sorbonne Universit\u00e9, site Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Intensive - R\u00e9animation (D\u00e9partement R3S), Paris, France; 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and APHP-6 Sorbonne Universit\u00e9, site Piti\u00e9-Salp\u00eatri\u00e8re, D\u00e9partement R3S (Respiration, R\u00e9animation, R\u00e9habilitation respiratoire, Sommeil), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Delemazure","sequence":"additional","affiliation":[{"name":"APHP-6 Sorbonne Universit\u00e9, site Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Intensive - R\u00e9animation (D\u00e9partement R3S), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Demoule","sequence":"additional","affiliation":[{"name":"APHP-6 Sorbonne Universit\u00e9, site Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Intensive - R\u00e9animation (D\u00e9partement R3S), Paris, France; and Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4031"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31189-2"},{"key":"e_1_3_3_5_2","first-page":"1","article-title":"Clinical characteristics and day-90 outcomes of 4,244 critically ill adults with COVID-19: a prospective cohort study","author":"COVID-ICU Group on behalf of the REVA Network and the COVID ICU Investigators","year":"2020","unstructured":"COVID-ICU Group on behalf of the REVA Network and the COVID ICU Investigators. 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