{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:49:36Z","timestamp":1775472576186,"version":"3.50.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The influence of physical function of individuals on long-term oxygen therapy (LTOT) on caregiver burden is underexplored. This study investigated the association of caregiver burden with physical function of individuals on LTOT and the association between caregiver\u2019s burden and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This was a cross-sectional study. Informal caregivers were assessed for burden using the Caregiver Burden Inventory (CBI), the European Quality of Life 5 Dimension questionnaire index (EQ-5D index) and its Visual Analog Scale (EQ-VAS). Physical function of subjects on LTOT was assessed by dyspnea, activities of daily living (ADLs), and mobility. Univariate and multivariate linear regression models were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Fifty-four caregivers (54.7 \u00b1 16.1 y, 74.1% female) were included. CBI total score was correlated with subject\u2019s dyspnea (r = 0.369,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .006) and ADLs (r = 0.300,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03). In the multivariate regression models, subject\u2019s physical function limitation due to dyspnea explained 26.4% of the CBI total score variance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005). In the CBI dimension analysis, the time-dependence caregiver burden was correlated with subject\u2019s dyspnea (r = 0.335,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01), ADLs (r = 0.436,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001), and mobility (r = \u22120.415,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002). CBI developmental and physical caregiver burden were correlated with dyspnea (r = 0.309,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02; r = 0.363,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .007) and ADLs (r = 0.274,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .045; r = 0.299,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03). Emotional caregiver burden was correlated with dyspnea (r = 0.333,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01). Higher CBI total score was correlated with worse quality of life on EQ-5D index (r\n                      <jats:sub>s<\/jats:sub>\n                      = \u22120.374,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .005) and EQ-VAS (r\n                      <jats:sub>s<\/jats:sub>\n                      = \u22120.494,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001) in caregivers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Increased caregiver burden was associated with higher physical limitation due to dyspnea and dependence in ADLs of individuals on LTOT. The increased burden was associated with a worse caregiver\u2019s quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09619","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T09:05:25Z","timestamp":1656407125000},"page":"1413-1419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Caregiver Burden Is Associated With the Physical Function of Individuals on Long-Term Oxygen Therapy"],"prefix":"10.1177","volume":"67","author":[{"given":"Luciana AS","family":"Jesus","sequence":"first","affiliation":[{"name":"Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Malaguti","sequence":"additional","affiliation":[{"name":"Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; and School of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah G","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe M","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brena P","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa T","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Home Care, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maycon M","family":"Reboredo","sequence":"additional","affiliation":[{"name":"Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; and School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie L","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, School of Primary and Allied Health Care, Monash University, Frankston, Victoria, Australia; and Centre for Allied Health Research and Education, Cabrini Health, Malvern, Victoria, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro F","family":"Cabral","sequence":"additional","affiliation":[{"name":"School of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Jos\u00e9","sequence":"additional","affiliation":[{"name":"Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; and School of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristino C","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; and Department of Physiotherapy, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01477-2017"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-206865"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2017.1283981"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2014.902458"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00010114"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17176427"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2020.05.019"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/26.3.260"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5126"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2016.04.007"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S76091"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1474515119850011"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13620"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.304"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-11692013000400005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.06.007"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/29.6.798"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.20344\/amp.1317"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.93.3.580"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2008000100010"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51512.x"},{"key":"e_1_3_3_26_2","volume-title":"Biostatistics: the bare essentials, 3rd edition","author":"Norman GR","year":"2008","unstructured":"Norman GR, , Streiner DL. 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