{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:16:49Z","timestamp":1778174209552,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Noninvasive respiratory support (NRS) has been used to treat acute respiratory failure outside the ICU, but existing data have left many knowledge gaps for managing NRS in general wards. The primary objective of this study was to describe indications, duration of treatment, and outcomes of subjects treated with NRS outside the ICU. The secondary objective was to compare outcomes based on age &lt; 80 or \u2265 80 y.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This retrospective observational study was conducted at Maggiore della Carit\u00e0 University Hospital in Novara, Italy, and included all patients treated with noninvasive ventilation (NIV) or CPAP outside the ICU from November 2017 to October 2018, with 1 year of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the 570 treatments performed, 383 subjects were analyzed, 136 NIV and 247 CPAP. Subjects\u2019 median (interquartile range [IQR]) age was 79 (72\u201385) y, and the main diagnoses of respiratory failure were cardiogenic pulmonary edema in 128 subjects (33%), pneumonia in 99 (26%), and COPD exacerbation in 52 (14%), with a median (IQR) treatment duration of 38 (16\u201374) h. Rapid response team visits lasted a median (IQR) 3 (2\u20136) d. Interface-related pressure lesions occurred in 13% of the subjects, in no case leading to definitive treatment discontinuation. Compared with the subjects \u2265 80 y old, the younger subjects had a median (IQR) longer hospitalization (16 [10\u201324] d vs 13 [9\u201320] d;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .003) but slightly decreased in-hospital mortality (21% vs 30%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .061) and a decreased post-discharged 1-year mortality in hospital survivors (25% vs 41%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002), differences observed only in the subjects treated with NIV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In a real-life setting outside the ICU, NIV and CPAP managed by a rapid response team with a daily visit in collaboration with ward staff highly experienced in NRS allowed us to treat the subjects without major complications. Post-discharge 1-year mortality was higher in the subjects \u2265 80 y old treated with NIV for acute hypercapnic respiratory failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09625","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T13:30:24Z","timestamp":1658237424000},"page":"1138-1146","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["One-Year Follow up of Noninvasive Respiratory Support in General Wards"],"prefix":"10.1177","volume":"67","author":[{"given":"Francesca","family":"Moretto","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Fracazzini","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Verdina","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."},{"name":"Unit of Medical Statistics, Department of Translational Medicine, University of Eastern Piedmont and Cancer Epidemiology, CPO Piemonte, Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Baino","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Grossi","sequence":"additional","affiliation":[{"name":"Anestesia e Terapia Intensiva, Azienda Ospedaliero Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Castello","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."},{"name":"Medicina D\u2019Urgenza, Azienda Ospedaliero Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianmaria","family":"Cammarota","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia, Universit\u00e0 degli Studi di Perugia, Perugia, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Balbo","sequence":"additional","affiliation":[{"name":"Pneumologia, Azienda Ospedaliero Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Paolo","family":"Sainaghi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."},{"name":"Medicina Interna, Azienda Ospedaliero Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Campanini","sequence":"additional","affiliation":[{"name":"Medicina Interna, Azienda Ospedaliero Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Pirisi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."},{"name":"Medicina Interna, Azienda Ospedaliero Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."},{"name":"Cardiologia, Azienda Ospedaliero Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Dal Molin","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale, Universit\u00e0 del Piemonte Orientale, Novara, Italy."},{"name":"Anestesia e Terapia Intensiva, Azienda 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