{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:25:58Z","timestamp":1780568758065,"version":"3.54.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Residual volume (RV) is a derived lung compartment that correlates with air trapping in the context of air flow obstruction on spirometry. The significance of an isolated elevation in RV in the absence of other pulmonary function test (PFT) abnormalities is not well defined. We sought to assess the clinical and radiologic findings associated with isolated elevation in RV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We searched our out-patient PFT database at Mayo Clinic (Rochester, Minnesota) from 2016\u20132018 for adult patients with isolated elevation in RV. We defined isolated elevation in RV as RV \u2265 upper limit of normal or \u2265 130% predicted with normal total lung capacity (TLC), spirometry, and diffusion capacity of the lung for carbon monoxide (D\n                      <jats:sub>LCO<\/jats:sub>\n                      ). We then matched this high-RV group by age and sex to an equal number of individuals with normal RV, TLC, spirometry, and D\n                      <jats:sub>LCO<\/jats:sub>\n                      (normal-RV group).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      We identified 169 subjects with isolated elevation in RV on PFTs, with a median age of 73 y; 55.6% were female, and median body mass index was 26.8 (vs 29.8 in the normal-RV group). The median RV was 3.08 L (134% predicted, interquartile range [IQR] 130\u2013141) in the high-RV group and 2.26 L (99% predicted, IQR 90\u2013109) in the normal-RV group\n                      <jats:italic toggle=\"yes\">(P<\/jats:italic>\n                      &lt; .001). Subjects with high RV were more likely to have smoked (54% vs 40%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01) and almost twice as likely to have a maximum voluntary ventilation &lt; 30 times the FEV\n                      <jats:sub>1<\/jats:sub>\n                      (21% vs 12%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02). Clinically, asthma (21% vs 11%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01) and non\u2013tuberculous mycobacterial lung infections (12% vs 2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001) were more prevalent in the high-RV group. On chest computed tomography, bronchiectasis (31% vs 15%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .008), bronchial thickening or mucus plugging (46% vs 22%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and emphysema (13% vs 5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .046) were more common in the high-RV group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Isolated elevation in RV on PFTs is a clinically relevant abnormality associated with airway-centered diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09687","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T14:00:49Z","timestamp":1653400849000},"page":"842-849","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Isolated Elevation in Lung Residual Volume Is Associated With Airway Diseases"],"prefix":"10.1177","volume":"67","author":[{"given":"Amjad N","family":"Kanj","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal F","family":"Samhouri","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Poliszuk","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiser G","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumedh S","family":"Hoskote","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.1.68"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2015.30.10.1459"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0121-2018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.05.118"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-020-00368-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.04.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01374"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1235"},{"key":"e_1_3_3_11_2","first-page":"OA4551","article-title":"Air trapping is associated with exercise capacity in persons without overt obstructive lung disease","volume":"48","author":"Arjomandi M","year":"2016","unstructured":"Arjomandi M, , Stiner R, , Zeng S, , Geerts J, , Gold W. Air trapping is associated with exercise capacity in persons without overt obstructive lung disease. European Respiratory Journal, 2016; 48(suppl 60):OA4551.","journal-title":"European Respiratory Journal"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.789058"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.10.031"},{"issue":"6","key":"e_1_3_3_14_2","first-page":"78","article-title":"Respiratory diagnostic tools in neuromuscular disease","volume":"5","author":"Chiang J","year":"2018","unstructured":"Chiang J, , Mehta K, , Amin R. Respiratory diagnostic tools in neuromuscular disease. Children (Basel, 2018; 5(6):78).","journal-title":"Children (Basel"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"issue":"3","key":"e_1_3_3_17_2","first-page":"270","article-title":"Single-breath diffusing capacity in a representative sample of the population of Michigan, a large industrial state. Predicted values, lower limits of normal, and frequencies of abnormality by smoking history","volume":"127","author":"Miller A","year":"1983","unstructured":"Miller A, , Thornton JC, , Warshaw R, , Anderson H, , Teirstein AS, , Selikoff IJ. Single-breath diffusing capacity in a representative sample of the population of Michigan, a large industrial state. Predicted values, lower limits of normal, and frequencies of abnormality by smoking history. 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