{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:35:21Z","timestamp":1775471721304,"version":"3.50.1"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Both nasal obstruction and sleep disturbance are common in patients with cystic fibrosis (CF). In patients with obstructive sleep apnea (OSA), studies suggest that these conditions are related and that nasal congestion improves with CPAP therapy. We hypothesized that subjects admitted to hospital for therapy of an exacerbation of CF would have both nasal symptoms and sleep disturbance and that these would improve with the initiation of nocturnal high-flow nasal cannula therapy (HFNC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Twenty-five subjects with an exacerbation of CF were enrolled to randomly receive either 5 d of nocturnal HFNC at 20 L\/min in the treatment group or 5 L\/min of nocturnal nasal cannula air at ambient temperature and humidity in the low-flow group. On the first and last day of the study, the Sino-Nasal Outcome Test (SNOT-20) was administered to evaluate nasal symptoms, and sleep quality was measured using the Actiwatch 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Fifteen subjects completed the study (6 HFNC, 9 low flow). We confirmed that subjects had significant sleep disturbance that did not improve over the 5 d of the study. Subjects also had disturbing nasal symptoms that significantly improved only in those receiving HFNC (pre 14 [20] vs post 6 [13],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Similar to what has been reported in older subjects with OSA, nocturnal HFNC improves sinonasal symptoms in subjects with an exacerbation of CF. There was no measurable effect on sleep quality, which may be due to the short duration of the study, or to subjects being evaluated while being treated in a hospital setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09890","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T14:06:28Z","timestamp":1685455588000},"page":"1527-1531","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nocturnal High-Flow Nasal Cannula Therapy and Sinonasal Symptoms During Cystic Fibrosis Exacerbations"],"prefix":"10.1177","volume":"68","author":[{"given":"Michael D","family":"Davis","sequence":"first","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research\/Pediatric Pulmonology, Allergy, and Sleep Medicine, Riley Hospital for Children at Indiana University School of Medicine, Indianapolis, Indiana; and Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Brockbank","sequence":"additional","affiliation":[{"name":"Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Hayden","sequence":"additional","affiliation":[{"name":"Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S","family":"Schechter","sequence":"additional","affiliation":[{"name":"Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce K","family":"Rubin","sequence":"additional","affiliation":[{"name":"Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09540726"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2915"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2008.04.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22485"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02214"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21607"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3259"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101279"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-018-0167-x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.07.002"},{"issue":"7","key":"e_1_3_2_12_2","first-page":"e9303","article-title":"Effect of high-flow nasal cannula on sleep-disordered breathing and sleep quality in patients with acute stroke","volume":"12","author":"Nakanishi N","year":"2020","unstructured":"Nakanishi N, , Suzuki Y, , Ishihara M, , Ueno Y, , Tane N, , Tsunano Y, et al. Effect of high-flow nasal cannula on sleep-disordered breathing and sleep quality in patients with acute stroke. Cureus, 2020; 12(7):e9303.","journal-title":"Cureus"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23749"},{"key":"e_1_3_2_14_2","first-page":"CD012979","article-title":"Medical interventions for chronic rhinosinusitis in cystic fibrosis","volume":"10","author":"Karanth TK","year":"2019","unstructured":"Karanth TK, , Karanth V, , Ward BK, , Woodworth BA, , Karanth L. Medical interventions for chronic rhinosinusitis in cystic fibrosis. Cochrane Database Syst Rev, 2019; 10:CD012979.","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_3_2_15_2","first-page":"341","article-title":"Sinonasal outcome test-22 and peak nasal inspiratory flow \u2013valuable tools in obstructive sleep apnoea","volume":"58","author":"Bengtsson C","year":"2020","unstructured":"Bengtsson C, , Jonsson L, , Theorell-Haglow J, , Holmstrom M, , Janson C, , Lindberg E. Sinonasal outcome test-22 and peak nasal inspiratory flow \u2013valuable tools in obstructive sleep apnoea. Rhinology, 2020; 58(4):341\u2013348.","journal-title":"Rhinology"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.0261"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13022"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21948"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22157"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.09890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.09890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.09890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:17:34Z","timestamp":1775467054000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.09890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.4187\/respcare.09890"],"URL":"https:\/\/doi.org\/10.4187\/respcare.09890","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,30]]}}}