{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:17:29Z","timestamp":1787620649458,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Patients requiring mechanical ventilation due to COVID-19 have different characteristics of evolution and outcome compared to the general ICU population. Although early weaning from mechanical ventilation is associated with improved outcomes, inadequate identification of patients unable to be weaned may lead to extubation failure and increased days on mechanical ventilation. Outcomes related to mechanical ventilation weaning in this population are scare and inconclusive. Therefore, the objective of this study was to describe the characteristics of mechanical ventilation weaning in subjects with acute respiratory failure induced by COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This was a multi-center, prospective cohort study. We included adult subjects requiring at least 12 h of mechanical ventilation due to COVID-19 infection admitted to any participating ICUs. Characteristics of the mechanical ventilation weaning and extubation process, as well as clinical results, were the primary outcome variables. Weaning types were defined according to previously described and internationally recognized categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Three hundred twenty-six subjects from 8 ICUs were included. A spontaneous breathing trial (SBT) was not performed in 52.1% of subjects. One hundred twenty-eight subjects were extubated, and 29.7% required re-intubation. All the subjects included could be classified by Weaning according to a New Definition (WIND) classification (group 0 = 52.1%, group 1 = 28.5%, group 2 = 8.0%, and group 3 = 11.3%) with statistically significant differences in duration of mechanical ventilation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and ICU length of stay (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The mechanical ventilation weaning process in subjects with COVID-19 was negatively affected by the disease, with many subjects never completing an SBT. Even though temporal variables were modified, the clinical outcomes in each weaning group were similar to those previously reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.09925","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:35:29Z","timestamp":1668512129000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Epidemiology of Weaning From Invasive Mechanical Ventilation in Subjects With COVID-19"],"prefix":"10.1177","volume":"68","author":[{"given":"Javier H","family":"Dorado","sequence":"first","affiliation":[{"name":"Cap\u00edtulo de Kinesiolog\u00eda Intensivista, Sociedad Argentina de Terapia Intensiva, CABA, Argentina; and Sanatorio Anchorena San Martin, Provincia de Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Navarro","sequence":"additional","affiliation":[{"name":"Cap\u00edtulo de Kinesiolog\u00eda Intensivista, Sociedad Argentina de Terapia Intensiva, CABA, Argentina; and Centro del Parque, CABA, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A","family":"Plotnikow","sequence":"additional","affiliation":[{"name":"Cap\u00edtulo de Kinesiolog\u00eda Intensivista, Sociedad Argentina de Terapia Intensiva, CABA, Argentina; Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud, CABA, Argentina; Hospital Brit\u00e1nico de Buenos Aires, CABA, Argentina; and Director del Grupo de Estudios Especializados en VM, Universidad Abierta Interamericana, CABA, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Gogniat","sequence":"additional","affiliation":[{"name":"Cap\u00edtulo de Kinesiolog\u00eda Intensivista, Sociedad Argentina de Terapia Intensiva, CABA, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Accoce","sequence":"additional","affiliation":[{"name":"Cap\u00edtulo de Kinesiolog\u00eda Intensivista, Sociedad Argentina de Terapia Intensiva, CABA, Argentina; Sanatorio Anchorena San Martin, Provincia de Buenos Aires, Argentina; and Universidad Abierta Interamericana. Facultad de Medicina y Ciencias de la Salud, CABA, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the EpVAr Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/2197-425X-3-S1-A426"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30560-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00229-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30316-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2169OC"},{"issue":"1","key":"e_1_3_2_9_2","first-page":"3","article-title":"Mechanical ventilation in Spain, 1998\u20132016: epidemiology and outcomes","volume":"45","author":"Pe\u00f1uelas O","year":"2021","unstructured":"Pe\u00f1uelas O, , Frutos-Vivar F, , Muriel A, , Mancebo J, , Garc\u00eda-Jim\u00e9nez A, , de Pablo R, et al. Mechanical ventilation in Spain, 1998\u20132016: epidemiology and outcomes. Med Intensiva, 2021; 45(1):3-13.","journal-title":"Med Intensiva"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2021.10.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00010206"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201602-0320OC"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60105-1"},{"issue":"1","key":"e_1_3_2_15_2","first-page":"43","article-title":"Sedation, delirium, and mechanical ventilation: the \u201cABCDE\u201d approach","volume":"17","author":"Morandi A","year":"2011","unstructured":"Morandi A, , Brummel NE, , Ely EW. Sedation, delirium, and mechanical ventilation: the \u201cABCDE\u201d approach. Curr Opin Crit Care, 2011; 17(1):43-49.","journal-title":"Curr Opin Crit Care"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4297-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000129"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003298"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e2017"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106038"},{"issue":"3","key":"e_1_3_2_21_2","first-page":"e0353","article-title":"ABCDEF bundle and supportive ICU practices for subjects with coronavirus disease 2019 infection: an international point prevalence study","volume":"3","author":"Liu K","year":"2021","unstructured":"Liu K, , Nakamura K, , Katsukawa H, , Elhadi M, , Nydahl P, , Ely EW, et al. ABCDEF bundle and supportive ICU practices for subjects with coronavirus disease 2019 infection: an international point prevalence study. Crit Care Explor, 2021; 3(3):e0353.","journal-title":"Crit Care Explor"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/08850666211020281"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_543_18"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000748"},{"issue":"1","key":"e_1_3_2_25_2","first-page":"35","article-title":"Structural capacity, technological human resources and mechanical ventilation requirements in 58 intensive care units in Argentina during the SARS-CoV-2 pandemic. A SATICOVID-19 study","volume":"82","author":"Estenssoro E","year":"2022","unstructured":"Estenssoro E, , Plotnikow G, , Loudet CI, , R\u00edos FG, , Kanoore Edul VS, , Andrian M, et al. Grupo de investigadores del estudio SATICOVID-19. Structural capacity, technological human resources and mechanical ventilation requirements in 58 intensive care units in Argentina during the SARS-CoV-2 pandemic. A SATICOVID-19 study. Medicina (B Aires), 2022; 82(1):35-46.","journal-title":"Medicina (B Aires)"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/08850666221098930"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132935"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00524-2020"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3596"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.6.1664"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1870-0"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1457-4"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.036"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.04.053"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.09925","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.09925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.09925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:30:02Z","timestamp":1787135402000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.09925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.4187\/respcare.09925"],"URL":"https:\/\/doi.org\/10.4187\/respcare.09925","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,15]]}}}