{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:33:20Z","timestamp":1775471600541,"version":"3.50.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Unplanned extubation (UE) is associated with adverse outcomes. The aim of the study was to compare the clinical outcomes in preterm infants who experienced at least one UE to those who did not experience any UE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The matched cohort study compared ventilated preterm infants &lt; 32 weeks who experienced UE to those who did not experience any UE. The main outcomes were duration of mechanical ventilation after matching, duration of hospital stay, retinopathy of prematurity (ROP) requiring intervention, and bronchopulmonary dysplasia (BPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Forty-seven infants were included in each group. The groups were matched for mechanical ventilation duration before UE, birth gestation, and birthweight. The duration of mechanical ventilation after matching (adjusted odds ratio [aOR] 14.8 [11.2\u201318.4],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = &lt;.001), the total length of stay in the hospital (aOR 16.4 [3.7\u201329.2],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01), and severe ROP (aOR 6.7 [1.7\u201327.0],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .007) were significantly higher in infants who experienced UE. After adjusting for mechanical ventilation duration, UE was not associated with ROP or BPD. However, infants who spent longer time on mechanical ventilation had higher odds of developing ROP (aOR 1.1 [1.0\u20131.2],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004) and BPD (aOR 1.5 [1.1\u20132.1],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01). Sensitivity analysis including infants who had UE and managed on noninvasive respiratory support showed significant association between UE and the outcomes of duration of mechanical ventilation, hospital length of stay, ROP, and BPD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Infants who experienced UE had higher odds of spending longer time on mechanical ventilation and spent significantly more days in the hospital.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.10005","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T01:50:23Z","timestamp":1663811423000},"page":"1320-1326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of Preterm Infants Who Experienced Unplanned Extubation"],"prefix":"10.1177","volume":"67","author":[{"given":"Vrinda","family":"Nair","sequence":"first","affiliation":[{"name":"Neonatal Unit, James Cook University Hospital, Middlesbrough, England, United Kingdom; and Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, England, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash Kannan","family":"Loganathan","sequence":"additional","affiliation":[{"name":"Neonatal Unit, James Cook University Hospital, Middlesbrough, England, United Kingdom; Clinical Academic Office, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, England, United Kingdom; and Department of Physics, University of Durham, Durham, England, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Smith","sequence":"additional","affiliation":[{"name":"Neonatal Unit, James Cook University Hospital, Middlesbrough, England, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithilesh Kumar","family":"Lal","sequence":"additional","affiliation":[{"name":"Neonatal Unit, James Cook University Hospital, Middlesbrough, England, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.01902.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3334"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.07643"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06721"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2932-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1603341"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.09.077"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-312962"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000406"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-2819"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002787"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.2401"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.10.042"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315993"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02129-2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2003.00545.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2011.08.004"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316464"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-1757"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01568.x"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.10005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.10005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.10005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:14:21Z","timestamp":1775466861000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.10005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.4187\/respcare.10005"],"URL":"https:\/\/doi.org\/10.4187\/respcare.10005","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,5]]}}}