{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:03:58Z","timestamp":1777910638513,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Hypoxemia is a relatively common complication in stable patients during fiberoptic bronchoscopy (FOB). To prevent this complication, high-flow nasal cannula (HFNC) has been described as an alternative to standard oxygen therapy. However, the advantages of HFNC over standard oxygen therapy in acute care patients receiving supplemental oxygen before FOB performed with an oral approach are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We conducted an observational study that involved subjects with a presumptive diagnosis of pneumonia and a clinical indication for a bronchial aspirate sample. The type of oxygen support (standard oxygen therapy vs HFNC) was selected according to availability. The oxygen flow in the HFNC group was 60 L\/min. In both groups, the F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      was set at 0.40. Hemodynamic, respiratory dynamics, and gas exchange data were collected at baseline, before, during, and 24 h after FOB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Forty subjects were included, 20 in each group (HFNC and standard oxygen therapy). The study was performed on day 5 of hospitalization in the HFNC group and on day 4 in the standard oxygen therapy group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .10). No significant between-group differences in baseline characteristics were observed. HFNC vs standard oxygen therapy was associated with a smaller decrease in S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      levels during the procedure (94% vs 90%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .040, respectively) and with less variation between the last S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      measured before FOB and the lowest S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      during FOB (\u0394 S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      ): 2% versus 4.5% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      In acute subjects who required oxygen support before FOB, the use of HFNC during FOB with an oral approach was associated with a smaller decrease in S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      and lower \u0394 S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      compared with standard oxygen therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.10598","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T07:33:48Z","timestamp":1678433628000},"page":"727-733","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Changes in Oxygen Saturation During Fiberoptic Bronchoscopy: High-Flow Nasal Cannula versus Standard Oxygen Therapy"],"prefix":"10.1177","volume":"68","author":[{"given":"Pedro Pablo","family":"Arias-Sanchez","sequence":"first","affiliation":[{"name":"Intermediate Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Ledesma","sequence":"additional","affiliation":[{"name":"Pneumology Service, Hospital Santa Ines, Cuenca, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johana","family":"Cobos","sequence":"additional","affiliation":[{"name":"Intermediate Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."},{"name":"Intensive Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Tirape","sequence":"additional","affiliation":[{"name":"Intermediate Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."},{"name":"Intensive Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betzy","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Intermediate Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."},{"name":"Intensive Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeimmy","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Intermediate Care Unit, Hospital Vicente Corral Moscoso, Cuenca, Ecuador."},{"name":"Intensive Care Unit, Hospital Vicente Corral 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