{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:32:14Z","timestamp":1775471534103,"version":"3.50.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Noninvasive respiratory support (NRS) is widely used in pediatric ICUs (PICUs). However, there is limited experience regarding the utilization of NRS in non-PICU settings. We aimed to evaluate the success rate of NRS in pediatric high-dependency units (PHDUs), identify predictors of NRS failure, quantify adverse events, and assess outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We included infants and children (&gt; 7 d to &lt; 13 y old) admitted to PHDU in 2 tertiary hospitals for acute respiratory distress over a 19-month period. Collected data included diagnosis, type and duration of NRS, adverse events, and the need for PICU transfer or invasive ventilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Two hundred and ninety-nine children were included, with a median age of 7 (interquartile range [IQR] 3\u201325) months and a median weight of 6.1 (IQR 4.3\u201310.5) kg. Bronchiolitis (37.5%), pneumonia (34.1%), and asthma (12.7%) were the most frequent diagnoses. Median NRS duration was 2 (IQR 1\u20133) d. At baseline, median S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      was 96% (IQR 90\u201399); median pH was 7.36 (IQR 7.31\u20137.41), and median P\n                      <jats:sub>\n                        CO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      was 44 (IQR 36\u201353) mm Hg. Overall, 234 (78.3%) children were successfully managed in PHDU, whereas 65 (21.7%) required transfer to PICU. Thirty-eight (12.7%) needed invasive ventilation on a median time of 43.5 (IQR 13.5\u2013108.0) h. On multivariable analysis, maximum F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      &gt; 0.5 (odds ratio 4.49 [95% CI 1.36\u201314.9],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01) and PEEP &gt; 7 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O (odds ratio 3.37 [95% CI 1.49\u20137.61],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004) were predictors for NRS failure. Significant apnea, cardiopulmonary resuscitation, and air leak syndrome were reported in 0.3, 0.7, and 0.7% children, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      In our cohort, we found NRS in PHDU safe and effective; however, maximum F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      &gt; 0.5 post treatment and PEEP &gt; 7 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O were associated with NRS failure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.10603","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T13:45:15Z","timestamp":1679924715000},"page":"1237-1244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcome of Noninvasive Respiratory Support in Pediatric High-Dependency Units for Acute Respiratory Distress"],"prefix":"10.1177","volume":"68","author":[{"given":"Khaloud S","family":"Al-Mukhaini","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Section, Department of Child Health, Royal Hospital, Muscat, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samiuddin","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Section, Department of Child Health, Royal Hospital, Muscat, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed K","family":"Al-Kharusi","sequence":"additional","affiliation":[{"name":"Pediatrics Section, Sohar Hospital, Sohar, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif SA","family":"Thani","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Section, Department of Child Health, Royal Hospital, Muscat, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghad M","family":"Al-Abdwani","sequence":"additional","affiliation":[{"name":"Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar A","family":"Al-Senaidi","sequence":"additional","affiliation":[{"name":"Pediatrics Residency Training Program, Oman Medical Specialty Board, Muscat, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed E","family":"Elkhamisy","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Section, Department of Child Health, Royal Hospital, Muscat, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence D","family":"Birru","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna A","family":"Al-Fahdi","sequence":"additional","affiliation":[{"name":"Pediatrics Residency Training Program, Oman Medical Specialty Board, Muscat, Oman."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001805"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21482"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2012.e16"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.01.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxy123"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22513"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_433_21"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1350-y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02130-2020"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03697-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.06.035"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001425"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000250"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-4083"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23626"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2094-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12509"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2015-204914"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-017-0785-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-122"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23988"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000387"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000225089.21176.0B"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2386-y"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000170612.16938.F6"},{"issue":"6","key":"e_1_3_2_27_2","first-page":"322","article-title":"The 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The cause of acute respiratory failure predicts the outcome of noninvasive ventilation in immunocompromised children. 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