{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:44:35Z","timestamp":1784630675823,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,3]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n Infants with hypoxic-ischemic encephalopathy are often treated with therapeutic hypothermia and high-frequency ventilation. Fluctuations in P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n during therapeutic hypothermia are associated with poor neurodevelopmental outcomes. Transcutaneous CO\n 2<\/jats:sub>\n monitors offer a noninvasive estimate of P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n represented by transcutaneously measured partial pressure of carbon dioxide (P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n ). We aimed to assess the precision between P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n and P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n values in neonates undergoing therapeutic hypothermia.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n This was a retrospective chart review of 10 neonates who underwent therapeutic hypothermia requiring respiratory support over 2 y. A range of 2\u201327 simultaneous P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n and P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n pairs of measurements per neonate were analyzed via linear mixed models and a Bland-Altman plot for multiple observations per neonate.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n A linear mixed-effect model demonstrated that P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n and P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n (controlling for sex) were similar. The 95% CI of the mean difference ranged from \u22122.3 to 5.7 mm Hg (\n P<\/jats:italic>\n = .41). However, precision was poor as the P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n ranged from > 18 mm Hg to < 13 mm Hg than P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n values for 95% of observations.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n The neonates\u2019 P\n \n tcCO\n 2<\/jats:sub>\n <\/jats:sub>\n was as much as 18 mm Hg higher to 13 mm Hg lower than the P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n 95% of the time. Transcutaneous CO\n 2<\/jats:sub>\n monitoring may not be a good trending tool, nor is it appropriate for estimating P\n \n aCO\n 2<\/jats:sub>\n <\/jats:sub>\n in patients undergoing therapeutic hypothermia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.10696","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T14:05:17Z","timestamp":1685455517000},"page":"339-344","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Precision Between Transcutaneous Carbon Dioxide Versus P\n \n aCO\n 2<\/sub>\n <\/sub>\n in Infants Undergoing Therapeutic Hypothermia"],"prefix":"10.1177","volume":"69","author":[{"given":"Pranav","family":"Garlapati","sequence":"first","affiliation":[{"name":"Dr Garlapati is affiliated with Newborn Specialists of Tulsa, Tulsa, Oklahoma. Drs Vali and Lakshminrusimha are affiliated with Department of Pediatrics, UC Davis Medical Center, Sacramento, California. Mr Smith is affiliated with Department of Respiratory Care, UC Davis Medical Center, Sacramento, California. Dr Zavorsky is affiliated with Department of Physiology and Membrane Biology, University of California, Davis, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Vali","sequence":"additional","affiliation":[{"name":"Dr Garlapati is affiliated with Newborn Specialists of Tulsa, Tulsa, Oklahoma. Drs Vali and Lakshminrusimha are affiliated with Department of Pediatrics, UC Davis Medical Center, Sacramento, California. Mr Smith is affiliated with Department of Respiratory Care, UC Davis Medical Center, Sacramento, California. Dr Zavorsky is affiliated with Department of Physiology and Membrane Biology, University of California, Davis, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[{"name":"Dr Garlapati is affiliated with Newborn Specialists of Tulsa, Tulsa, Oklahoma. Drs Vali and Lakshminrusimha are affiliated with Department of Pediatrics, UC Davis Medical Center, Sacramento, California. Mr Smith is affiliated with Department of Respiratory Care, UC Davis Medical Center, Sacramento, California. Dr Zavorsky is affiliated with Department of Physiology and Membrane Biology, University of California, Davis, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Smith","sequence":"additional","affiliation":[{"name":"Dr Garlapati is affiliated with Newborn Specialists of Tulsa, Tulsa, Oklahoma. Drs Vali and Lakshminrusimha are affiliated with Department of Pediatrics, UC Davis Medical Center, Sacramento, California. Mr Smith is affiliated with Department of Respiratory Care, UC Davis Medical Center, Sacramento, California. Dr Zavorsky is affiliated with Department of Physiology and Membrane Biology, University of California, Davis, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald S","family":"Zavorsky","sequence":"additional","affiliation":[{"name":"Dr Garlapati is affiliated with Newborn Specialists of Tulsa, Tulsa, Oklahoma. Drs Vali and Lakshminrusimha are affiliated with Department of Pediatrics, UC Davis Medical Center, Sacramento, California. Mr Smith is affiliated with Department of Respiratory Care, UC Davis Medical Center, Sacramento, California. Dr Zavorsky is affiliated with Department of Physiology and Membrane Biology, University of California, Davis, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80649-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066605278652"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2006.02.007"},{"issue":"5","key":"e_1_3_2_6_2","first-page":"480","article-title":"Transcutaneous carbon dioxide monitoring with reduced-temperature probes in very low birthweight infants","volume":"34","author":"Aly S","year":"2017","unstructured":"Aly S, , El-Dib M, , Mohamed M, , Aly H. Transcutaneous carbon dioxide monitoring with reduced-temperature probes in very low birthweight infants. Am J Perinatol, 2017; 34(5):480\u2013485.","journal-title":"Am J Perinatol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.590601"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-322138"},{"issue":"3","key":"e_1_3_2_9_2","first-page":"150","article-title":"Transcutaneous analysis of arterial PCO2","volume":"16","author":"Hazinski TA","year":"1982","unstructured":"Hazinski TA, , Severinghaus JW. Transcutaneous analysis of arterial PCO2. Med Instrum, 1982; 16(3):150\u2013153.","journal-title":"Med Instrum"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/10543400701329422"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0962280211402548"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2307\/2532051"},{"issue":"1","key":"e_1_3_2_13_2","first-page":"324","article-title":"A note on the concordance correlation coefficient","volume":"56","author":"Lin L","year":"2000","unstructured":"Lin L. A note on the concordance correlation coefficient. Biometrics, 2000; 56(1):324\u2013325.","journal-title":"Biometrics"},{"key":"e_1_3_2_14_2","unstructured":"Royal College of Pathologists of Australasia. Quality Assurance Programs. Aug ust 2021. Available at: https:\/\/rcpaqap.com.au\/resources\/chemical-pathology-analytical-performance-specifications\/. Accessed April 12 2023."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7049.106"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.00766.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950120305"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201701-034FR"},{"issue":"1","key":"e_1_3_2_19_2","first-page":"69","article-title":"Temperature correction of blood gas values","volume":"1","author":"Shapiro BA","year":"1995","unstructured":"Shapiro BA. Temperature correction of blood gas values. Respir Care Clin N Am, 1995; 1(1):69\u201376.","journal-title":"Respir Care Clin N Am"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/69.1.51"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70230-1"},{"issue":"12","key":"e_1_3_2_22_2","first-page":"I103","article-title":"Effects of pH management during deep hypothermic bypass on cerebral microcirculation: alpha-stat versus pH-stat","volume":"106","author":"Duebener LF","year":"2002","unstructured":"Duebener LF, , Hagino I, , Sakamoto T, , Mime LB, , Stamm C, , Zurakowski D, et al. Effects of pH management during deep hypothermic bypass on cerebral microcirculation: alpha-stat versus pH-stat. Circulation, 2002; 106(12 Suppl 1):I103\u2013108.","journal-title":"Circulation"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00018"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.07.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01134-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01177-5"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.1998.10480559"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.10696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.10696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.10696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:26:45Z","timestamp":1775467605000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.10696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.4187\/respcare.10696"],"URL":"https:\/\/doi.org\/10.4187\/respcare.10696","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,28]]}}}