{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:43:46Z","timestamp":1788997426577,"version":"build-2803163510"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Exercise-induced O\n                      <jats:sub>2<\/jats:sub>\n                      desaturation contributes to dyspnea and exercise intolerance in various respiratory diseases. This study assessed whether automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration was superior to fixed-flow O\n                      <jats:sub>2<\/jats:sub>\n                      to improve exertional dyspnea and walking exercise endurance. We also aimed at evaluating possible additive effects of high-flow nasal cannula coupled with automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration on these outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Subjects with chronic respiratory diseases and exercise-induced desaturation performed a 3-min constant-speed shuttle test (CSST) and an endurance shuttle walking test (ESWT) with either (1) fixed-flow O\n                      <jats:sub>2<\/jats:sub>\n                      , (2) automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration targeting an S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      of 94% (\u00b1 2%), and (3) automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration + high-flow nasal cannula according to a randomized sequence. The main outcome was Borg dyspnea score at the end of the 3-min CSST. Secondary outcomes included endurance time and dyspnea during ESWT and oxygenation status during exercise.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Ten subjects with COPD, 10 with interstitial lung disease, 5 with pulmonary hypertension, and 3 with cystic fibrosis completed the study. Compared to fixed-flow O\n                      <jats:sub>2<\/jats:sub>\n                      , automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration did not reduce dyspnea at the end of the 3-min CSST. Endurance time during the ESWT was prolonged with automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration (mean difference 298 [95% CI 205\u2013391] s,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and dyspnea at isotime was reduced. No further improvement was noted when high-flow nasal cannula was added to automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration. Compared to fixed-flow O\n                      <jats:sub>2<\/jats:sub>\n                      , O\n                      <jats:sub>2<\/jats:sub>\n                      flows were higher with automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration, resulting in better oxygenation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      Automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration was superior to fixed-flow O\n                      <jats:sub>2<\/jats:sub>\n                      to alleviate dyspnea and improve exercise endurance during the ESWT in subjects with a variety of chronic respiratory diseases. Adding high-flow nasal cannula to automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration provided no further benefits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.10810","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T11:33:48Z","timestamp":1690284828000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Automated O\n                    <sub>2<\/sub>\n                    Titration Alone or With High-Flow Nasal Cannula During Walking Exercise in Chronic Lung Diseases"],"prefix":"10.1177","volume":"69","author":[{"given":"Felix-Antoine","family":"V\u00e9zina","sequence":"first","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada; and Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Qu\u00e9bec City, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alexandre","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9milie","family":"Breton-Gagnon","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Dion","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Viglino","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada; and Universit\u00e9 Grenoble Alpes, Laboratoire Hypoxie-Physiopathologie HP2 INSERM U1300, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascalin","family":"Roy","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, 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